Hydroflumethiazide

  • Bristab
  • Bristurin
  • Methforylthiazidine
  • Trifluoromethylhydrothiazide
  • 6-Trifluoromethyl-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine-1,1-dioxide
  • 7-Sulfamyl-6-trifluoromethyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide
Formula
C8H8F3N3O4S2
Structure
Description
Crystals. Odorless.
Uses
Therap cat: antihypertensive, diuretic.

Registry Numbers and Inventories.
CAS
135-09-1
EC (EINECS/ELINCS)
205-173-8
RTECS
DK9625000
RTECS class
Drug
Merck
12,4830
Beilstein/Gmelin
342692
Beilstein Reference
4-27-00-08035
Austrailia AICS
Listed
New Zealand
Listed

Properties.
Formula
C8H8F3N3O4S2
Formula mass
331.3
Melting point, °C
271 - 274
Solubility in water
Insoluble
Refractive index
1.5403
pKa/pKb
8.63 (pKa)
Partition coefficient, pKow
0.36

Hazards and Protection.
Storage
Commercially available hydroflumethiazide tablets should be stored at room temperature (approximately 25C).
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Respirators
Use NIOSH/MSHA approved respirator appropriate for exposure of concern.
Small spills/leaks
Evacuate area and ventilate. Wear protective equipment. If required, use an inert absrobent. Sweep up and place in an appropriate container for disposal. Wash contaminated surfaces.
Stability
Unstable in alkaline solution.
Incompatibilities
Strong oxidizing agents.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.

Health.
Exposure effects
in overdose lethargy and coma have been reported in children ingesting thiazide diuretics. Altered mental status, headache, hypertonia, muscle weakness, and seizures may develop secondary to diuretic-induced electrolyte abnormalities. Ototoxicity occurs rarely and is usually reversible.
   Inhalation
Noncardiogenic pulmonary edema after hydrochlorothiazide ingestion has been reported and is believed to be an idiosyncratic reaction.

First aid
 
   Ingestion
Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control center for advice about whether to induce vomiting. If possible, do not leave individual unattended.
   Inhalation
If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.
   Skin
Remove contaminated clothing. Wash exposed area with soap and water. If symptoms persist, seek medical attention. Launder clothing before reuse.
   Eyes
If symptoms develop, immediately move individual away from exposure and into fresh air. Flush eyes gently with water for at least 15 minutes while holding eyelids apart; seek immediate medical attention.

Transport.