Hydroxyurea

  • Hydroxycarbamide
Formula
H2NCONHOH
Structure
Description
Odorless or almost odorless white to off-white crystalline solid. Tasteless.
Uses
Medication.

Registry Numbers and Inventories.
CAS
127-07-1
EC (EINECS/ELINCS)
204-821-7
R 46 61
RTECS
YT4900000
RTECS class
Tumorigen; Drug; Mutagen; Reproductive Effector; Human Data; Primary Irritant
UN (DOT)
2811
Merck
13,4874
Beilstein/Gmelin
1741548
Beilstein Reference
4-03-00-00170
Swiss Giftliste 1
G-5436
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed

Properties.
Formula
CH4N2O2
Formula mass
76.06
Melting point, °C
142 - 144
Boiling point, °C
296
Critical temperature
528
Critical pressure
102.6
Solubility in water
Soluble
Partition coefficient, pKow
-1.80

Hazards and Protection.
Storage
Store in a cool, dry, well-ventilated area away from incompatible substances. Keep containers tightly closed.
Handling
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use only in a well ventilated area. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks
Clean up spills immediately, using the appropriate protective equipment. Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions. Provide ventilation.
Stability
Stable under normal temperatures and pressures.
Incompatibilities
Strong oxidizing agents.
Decomposition
Nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide, nitrogen.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing media: Use agent most appropriate to extinguish fire. In case of fire use water spray, dry chemical, carbon dioxide, or appropriate foam.
Fire potential
This material is probably combustible.
Health
1
 
Flammability
0
 
 
Reactivity
0
 

Health.
Poison_Class
1*
Exposure effects
Hydroxyurea crosses the placenta in animals, and is embryotoxic.
   Ingestion
May cause bone marrow depression. Ingestion of large amounts may cause nausea and vomiting, which can produce dehydration, internal organ congestion and possibly coma. May cause microcytosis (smaller than normal red blood cells), normocytic anemia (reduced red blood cell count), luekopenia(reduced white blood cell count), thrombocytopenia (decreased number of blood platelets) and other blood abnormalities.
   Inhalation
Inhalation of dust may cause respiratory tract irritation.
   Skin
May cause skin irritation. May cause dermatitis.
   Eyes
May cause eye irritation.

First aid
 
   Ingestion
If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid.
   Inhalation
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid if cough or other symptoms appear.
   Skin
Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
   Eyes
Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Transport.
UN number
2811
Response guide