(-)-Hyoscyamine

  • (-)-Atropine
  • Daturine
  • Duboisine
  • L-Hyoscamine
  • L-Hyoscyamine
  • (S)-(-)-Hyoscyamine
Formula
C17H23NO3
Structure
Description
Silky, tetragonal needles from evaporating alcohol.
Uses
drug for treatment of organophosphorus poisoning

Registry Numbers and Inventories.
CAS
101-31-5
EC (EINECS/ELINCS)
202-933-0
EC Index Number
614-012-00-4
EC Class
Very toxic
RTECS
NH0875000
RTECS class
Human Data; Natural Product
Merck
12,4907
Beilstein/Gmelin
91259
Beilstein Reference
5-21-01-00235
Canada DSL/NDSL
NDSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed

Properties.
Formula
C17H23NO3
Formula mass
289.37
Melting point, °C
108.5
Solubility in water
3 g/L

Hazards and Protection.
Storage
Keep well closed and protect from light and heat.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Respirators
Use NIOSH/MSHA approved respirator appropriate for exposure of concern.
Small spills/leaks
Evacuate area and ventilate. Wear protective equipment. If required, use an inert absrobent. Sweep up and place in an appropriate container for disposal. Wash contaminated surfaces.
Stability
Affected by light and heat.
Incompatibilities
Strong oxidizing agents.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.

Health.
Exposure effects
Vital sign changes include rapid heart rate and elevated blood pressure. Both elevated body temperature and reduced body temperature have been reported, but elevated body temperature is more common. toxic psychosis (disorientation, delirium, hallucinations, and paranoia associated with anxiety, agitation, and hyperactivity) has been reported. Memory loss has also been noted as a toxic anticholinergic effect. Seizures, dystonic reactions, and dyskinesias may occur at recommended doses. Severe poisoning may produce coma, medullary paralysis, and death.
   Ingestion
Decreased gastric motility, diminished bowel sounds, esophageal atony and dilatation, colonic distention, and paralytic ileus may occur as a result of anticholinergic toxicity.
   Inhalation
Respiratory depression, respiratory failure, and aspiration may occur in severe overdoses.
   Skin
Warm red skin with decreased sweating is common. Delayed hypersensitivity has also been reported.
   Eyes
Warm red skin, decreased sweating, dry oral mucous membranes, and widely dilated pupils are common.

First aid
 
   Ingestion
Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control center for advice about whether to induce vomiting. If possible, do not leave individual unattended.
   Inhalation
If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.
   Skin
Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
   Eyes
If symptoms develop, immediately move individual away from exposure and into fresh air. Flush eyes gently with water for at least 15 minutes while holding eyelids apart; seek immediate medical attention.

Transport.