Indapamide

  • Veroxil
  • Tandix
  • Lonzol
  • Natrilix
  • N-(4-Chloro-3-sulfamoylbenzamido)-2-methylindoline
  • 3-(Aminosulfonyl)-4-chloro-N-(2,3-dihydro-2-methyl-1H-indol-1-yl)benzamide
Formula
C16H16ClN3O3S
Structure
Uses
A thiazide-like diuretic used, either alone or in combination with other drugs, to treat high blood pressure and to prevent salt and fluid retention associated with heart failure.

Registry Numbers and Inventories.
CAS
26807-65-8
EC (EINECS/ELINCS)
248-012-7
RTECS
CV2451200
RTECS class
Drug; Reproductive Effector
Merck
12,4969
Beilstein/Gmelin
1604026
Beilstein Reference
5-20-06-00348
Canada DSL/NDSL
DSL
New Zealand
Listed
Korea ECL
Listed

Properties.
Formula
C16H16ClN3O3S
Formula mass
365.84
Solubility in water
Insoluble
pKa/pKb
9.35 (pKa)

Hazards and Protection.
Protection
Wear appropriate government approved respirator, chemical-resistant gloves, safety goggles, other protective clothing.
Small spills/leaks
Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.
Stability
Stable at normal temperatures and pressures.
Decomposition
Carbon monoxide, Carbon dioxide, Nitrogen oxides, Sulfur oxides.

Fire.
Fire fighting
Extinguish using Water spray. Carbon dioxide, dry chemical powder, or appropriate foam. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
Hazards
Emits toxic fumes under fire conditions.

Health.
Exposure effects
Avoid contact and inhalation. Target organ(s): Kidneys.

First aid
 
   Ingestion
If swallowed, wash out mouth with water provided person is conscious. Call a physician.
   Inhalation
If inhaled, remove to fresh air. If breathing becomes difficult, call a physician.
   Skin
In case of skin contact, flush with copious amounts of water for at least 15 minutes. Remove contaminated clothing and shoes. Call a physician.
   Eyes
In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician.

Transport.