Indole

  • 2,3-Benzopyrrole
  • 1-Azaindene
  • 1-Benzazole
  • 1H-Indole
  • Benzo[b]pyrrole
  • Ketole
Formula
C8H7N
Structure
Description
Leaflets (water, petroleum), crystals (ether). Almost floral odor when highly purified, otherwise exhibits characteristic
Uses
Used in perfumery.

Registry Numbers and Inventories.
CAS
120-72-9
EC (EINECS/ELINCS)
204-420-7
EC Class
harmful
R 21/22 41
S 26 36/37/39
RTECS
NL2450000
RTECS class
Tumorigen; Primary Irritant
UN (DOT)
2811
Merck
13,4985
Beilstein/Gmelin
107693
Beilstein Reference
5-20-07-00005
EPA OPP
25000
Swiss Giftliste 1
G-3848
Canada DSL/NDSL
DSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C8H7N
Formula mass
117.16
Melting point, °C
50 - 51
Boiling point, °C
254 - 255
Vapor pressure, mmHg
0.03 (25 C)
Density
1.22 g/cm3
Solubility in water
Slightly soluble
Surface tension
37.39 g/s2 (99.5 C)
Partition coefficient, pKow
2.14
Heat of vaporization
47.1 kJ/mol
Heat of combustion
-428 kJ/mol

Hazards and Protection.
Storage
Keep containers tightly closed. Store protected from moisture. Store protected from light and air. Store in a cool, dry area away from incompatible substances.
Handling
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Do not get in eyes, on skin, or on clothing. Do not ingest or inhale. Store protected from light. Store protected from air. Keep from contact with moist air and steam.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves and clothing to prevent skin exposure. Clothing: Wear appropriate protective clothing to minimize contact with skin.
Respirators
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.
Small spills/leaks
Wash area with soap and water. Clean up spills immediately, using the appropriate protective equipment. Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions. Provide ventilation.
Disposal code
3
Stability
Stable under normal shipping and handling conditions. However, may decompose if exposed to moist air or water. Air sensitive Volatile in steam. Substance may discolor on exposure to light.
Incompatibilities
Strong oxidizing agents, iron, iron salts, moisture, air, direct light.
Decomposition
Nitrogen oxides, carbon monoxide, carbon dioxide.

Fire.
Flash Point,°C
108
Upper exp. limit, %
8.1
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. To extinguish fire, use carbon dioxide, dry chemical powder or water spray.
Fire potential
Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes.
Hazards
Contact with metals may evolve flammable hydrogen gas.
Combustion products
Fire may produce irritating, corrosive and/or toxic gases.
Health
2
 
Flammability
1
 
 
Reactivity
1
 

Health.
Poison_Class
4
Exposure effects
Animal studies have reported the development of tumors.
   Ingestion
Causes gastrointestinal irritation with nausea, vomiting and diarrhea. May be harmful if swallowed. May cause headache.
   Inhalation
Causes irritation of the mucous membrane and upper respiratory tract. May cause headache, nausea, and vomiting.
   Skin
Causes skin irritation. Harmful if absorbed through the skin. Substance is readily absorbed through the skin.
   Eyes
Causes severe eye irritation and possible injury.

First aid
 
   Ingestion
Never give anything by mouth to an unconscious person. Get medical aid immediately. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
   Inhalation
Get medical aid immediately. Remove from exposure to fresh air immediately. Do not use mouth-to-mouth respiration if victim ingested or inhaled the substance; induce artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device.
   Skin
Get medical aid immediately. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
   Eyes
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately. Do NOT allow victim to rub or keep eyes closed. Extensive irrigation is required (at least 30 minutes).

Transport.
UN number
2811
Response guide
Hazard class
6.1
Packing Group
I; II; III
 
9. Aromatic amines
HS Code
2933 99 20