Indomethacin

  • N-p-Chlorbenzoyl-5-methoxy-2-methylindole-3-acetic acid
  • 1-(p-Chlorobenzoyl)-5-methoxy-2-methylindole-3-acetic acid
  • alpha-(1-(p-Chlorobenzoyl)-2-methyl-5-methoxy-3-Indolyl)acetic acid
  • 1H-Indole-3-acetic acid, 1-(4-Chlorobenzoyl)-5-methoxy-2-methyl
  • Indomecol
Formula
C19H16ClNO4
Structure
Description
Crystals.
Uses
Medication.

Registry Numbers and Inventories.
CAS
53-86-1
EC (EINECS/ELINCS)
200-186-5
RTECS
NL3500000
RTECS class
Tumorigen; Drug; Mutagen; Reproductive Effector; Human Data
Merck
12,4998
Beilstein/Gmelin
497341
Beilstein Reference
5-22-05-00239
Canada DSL/NDSL
DSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C19H16ClNO4
Formula mass
357.79
Melting point, °C
163
Boiling point, °C
575
Vapor pressure, mmHg
5E-14 (25 C)
Solubility in water
Slightly soluble
pKa/pKb
4.17 (pKa)
Partition coefficient, pKow
4.27
Heat of fusion
39.4 kJ/mol
Heat of vaporization
90.6 kJ/mol

Hazards and Protection.
Storage
Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Respirators
Wear a NIOSH-approved half face respirator equipped with a combination filter cartridge, i.e. organic vapor/acid gas/HEPA (specific for organic vapors, HCl, acid gas, SO2 and a high efficiency particulate filter).
Small spills/leaks
Should a spill occur while you are handling this chemical, you should dampen the solid spill material with alcohol, then transfer the dampened material to a suitable container. Use absorbent paper dampened with alcohol to pick up any remaining material. Seal the absorbent paper, and any of your clothes, which may be contaminated, in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with alcohol followed by washing with a strong soap and water solution. Do not reenter the contaminate area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.
Stability
Sensitive to light stable in neutral or slightly acidic media, decomp by strong alkali stable in air and in heat under usual prevailing temperature conditions compressed tablets harden on storage.

Fire.
Flash Point,°C
301
Fire fighting
This compound is not very flammable but any fire involving this compound may produce dangerous vapors. You should evacuate the area. All firefighters should wear full-body protective clothing and use self-contained breathing apparatuses. You should extinguish any fires involving this chemical with a dry chemical, carbon dioxide, foam, or halon extinguisher.

Health.
Exposure effects
Disorientation, mental confusion, and lethargy have been reported. Headache, dizziness, vertigo, and stupor may also occur, as these have been noted at therapeutic doses.
   Inhalation
May cause gastrointestinal discomfort and possibly ulcerations. May aggravate psychiatric disturbances, epilepsy, and parkinsonism. May cause drowsiness and headache.
   Skin
See inhalation.
   Eyes
See inhalation

First aid
 
   Ingestion
If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. MMEDIATELY transport the victim to a hospital.
   Inhalation
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used.
   Skin
IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.
   Eyes
First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

Transport.