Indoprofen

  • a-Methyl-p-(1-oxo-2-isoindolinyl)benzeneacetic acid
  • 2-[4-(1-Oxo-2-isoindolinyl)phenyl]propanoic acid
  • dl-a-[4-(1-Oxo-2-isoindolinyl)phenyl]propionic acid
  • 1-Oxo-2-[p-[(a-methyl)carboxymethyl]phenyl]isoindoline
Formula
C17H15NO3
Structure
Uses
Potential treatment for spinal muscular atrophy.

Registry Numbers and Inventories.
CAS
31842-01-0
EC (EINECS/ELINCS)
250-833-0
22 36/37/39 45
RTECS
MU6645000
RTECS class
Drug
UN (DOT)
2811
Merck
12,4999
Beilstein/Gmelin
5578976
Beilstein Reference
6-21
Austrailia AICS
Listed

Properties.
Formula
C17H15NO3
Formula mass
281.31
Melting point, °C
208 - 210
Boiling point, °C
511
Vapor pressure, mmHg
3E-11 (25 C)
Solubility in water
Soluble
pKa/pKb
4.39 (pKa)
Heat of vaporization
82.4 kJ/mol

Hazards and Protection.
Protection
Wear appropriate government approved respirator, chemical-resistant gloves, safety goggles, other protective clothing.
Respirators
Wear positive pressure self-contained breathing apparatus (SCBA).
Small spills/leaks
Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.
Stability
Stable at normal temperatures and pressures.
Decomposition
Thermal decomposition may produce carbon monoxide, carbon dioxide, and nitrogen oxides.

Fire.
Flash Point,°C
263
Fire fighting
Extinguish using Water spray. Carbon dioxide, dry chemical powder, or appropriate foam. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
Fire potential
Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes.
Hazards
Emits toxic fumes under fire conditions.
Combustion products
Fire may produce irritating, corrosive and/or toxic gases.

Health.
Exposure effects
Toxic. Toxic if swallowed. Limited evidence of a carcinogenic effect. Possible carcinogen.
   Ingestion
Harmful if swallowed.
   Inhalation
TOXIC; inhalation, ingestion, or skin contact with material may cause severe injury or death. Effects of contact or inhalation may be delayed.
   Skin
Contact with molten substance may cause severe burns to skin and eyes. See Inhalation.
   Eyes
See Inhalation.

First aid
 
   Ingestion
If swallowed, wash out mouth with water provided person is conscious. Call a physician.
   Inhalation
If inhaled, remove to fresh air. If breathing becomes difficult, call a physician.
   Skin
In case of skin contact, flush with copious amounts of water for at least 15 minutes. Remove contaminated clothing and shoes. Call a physician.
   Eyes
In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician.

Transport.
UN number
2811
Response guide
Hazard class
6.1
Packing Group
III