Isopropyl acetate

  • Acetic acid, isopropyl ester
  • sec-Propyl acetate
  • 1-Methylethyl acetate
  • 2-Propyl acetate
  • 2-Acetoxypropane
Formula
CH3COOCH(CH3)2
Structure
Description
Clear, colorless liquid with an acetic odor.
Uses
Solvent for cellulose derivatives, plastics, oils, and fats, in perfumery.

Registry Numbers and Inventories.
CAS
108-21-4
EC (EINECS/ELINCS)
203-561-1
EC Index Number
607-024-00-6
EC Class
Highly flammable; Irritant; Repeated exposure may cause skin dryness or cracking; Vapours may cause drowsiness and dizziness
R 11 36 66 67
S 16 26 29 33
RTECS
AI4930000
RTECS class
Human Data; Primary Irritant
UN (DOT)
1220
Merck
13,5225
Beilstein/Gmelin
1740761
Beilstein Reference
4-02-00-00141
EPA OPP
508100
Swiss Giftliste 1
G-1711
Canada DSL/NDSL
DSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C5H10O2
Formula mass
102.13
Melting point, °C
-62
Boiling point, °C
85
Vapor pressure, mmHg
61 (25 C)
Vapor density (air=1)
3.5
Saturation Concentration
6.25% (20 C)
Evaporization number
3.0 (butyl acetate=1)
Odor Threshold Odor threshold 0.19 mg/m3
Critical temperature
257
Critical pressure
32.4
Density
0.8732 g/cm3
Solubility in water
30 g/L (20 C)
Viscosity
0.0049 g/(cm s) (25 C)
Surface tension
22.1 g/s2 (21 C)
Refractive index
1.4862 (20 C)
Dipole moment
1.87 (25 C)
Partition coefficient, pKow
1.06
Heat of vaporization
32.9 kJ/mol
Heat of combustion
-2064 kJ/mol

Hazards and Protection.
Storage
Keep away from heat, sparks, and flame. Keep away from sources of ignition. Store in a tightly closed container. Keep from contact with oxidizing materials. Store in a cool, dry, well-ventilated area away from incompatible substances.
B2
Handling
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Ground and bond containers when transferring material. Avoid contact with eyes, skin, and clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Avoid contact with heat, sparks and flame. Avoid ingestion and inhalation. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks
Absorb spill with inert material, (e.g., dry sand or earth), then place into a chemical waste container. Avoid runoff into storm sewers and ditches which lead to waterways. Clean up spills immediately, using the appropriate protective equipment. Remove all sources of ignition. Provide ventilation. A vapor suppressing foam may be used to reduce vapors.
Disposal code
1
Stability
Stable under normal temperatures and pressures.
Incompatibilities
Oxidizing agents, strong acids, nitrates, plastics, rubber, alkalies.
Decomposition
Carbon monoxide, carbon dioxide.

Fire.
Flash Point,°C
2
Autoignition, °C
479
Upper exp. limit, %
87.2
Lower exp. limit, %
1.8
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Do not extinguish fire unless flow can be stopped. Use water in flooding quantities as fog. Solid streams of water may be ineffective. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Use alcohol foam, dry chemical or carbon dioxide.
Fire potential
Flammable liquid and vapor.
Hazards
Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. May polymerize explosively when heated or involved in a fire. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.
Combustion products
Fire may produce irritating, corrosive and/or toxic gases.
Health
1
 
Flammability
3
 
 
Reactivity
0
 

Health.
Exposure limit(s)
TLV: 250 ppm; 1040 mg/m3 (as TWA) (ACGIH 1997). TLV (as STEL): 310 ppm; 1290 mg/m3 (ACGIH 1997). OSHA PEL: TWA 250 ppm (950 mg/m3) NIOSH REL: See Appendix D NIOSH IDLH: 1800 ppm
Poison_Class
5
Exposure effects
Chronic inhalation and ingestion may cause effects similar to those of acute inhalation and ingestion. Prolonged or repeated skin contact may cause defatting and dermatitis. Chronic exposure may cause liver damage.
   Ingestion
May cause gastrointestinal irritation with nausea, vomiting and diarrhea. May cause central nervous system depression, characterized by excitement, followed by headache, dizziness, drowsiness, and nausea. Advanced stages may cause collapse, unconsciousness, coma and possible death due to respiratory failure.
   Inhalation
Inhalation of high concentrations may cause central nervous system effects characterized by headache, dizziness, unconsciousness and coma. Inhalation of vapor may cause respiratory tract irritation. May cause effects similar to those described for ingestion. May cause narcotic effects in high concentration. Causes irritation of mucous membrane.
   Skin
Prolonged and/or repeated contact may cause defatting of the skin and dermatitis. May cause skin burns. Chronic exposure may cause liver damage.
   Eyes
Causes eye irritation.

First aid
 
   Ingestion
Do NOT induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
   Inhalation
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. DO NOT use mouth-to-mouth respiration.
   Skin
Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
   Eyes
Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Transport.
UN number
1220
Response guide
Hazard class
3
Packing Group
II
 
USCG CHRIS Code
IAC
 
HS Code
2915 39 10
 
Std. Transport #
4909210
 
IMO Chemical Code
18
IMO Pollution Category
III