Isopropyl chloroformate

  • Carbonochloridic acid, 1-methylethyl ester
  • Isopropyl chlorocarbonate
  • Chloroformic acid, isopropyl ester
Formula
C4H7ClO2
Structure
Description
Colorless liq. Pungent.
Uses
Chemical intermediate for free-radical polymerization initiators, organic synthesis.

Registry Numbers and Inventories.
CAS
108-23-6
EC (EINECS/ELINCS)
203-563-2
RTECS
LQ6475000
RTECS class
Primary Irritant
UN (DOT)
2407
Beilstein/Gmelin
506416
Beilstein Reference
4-03-00-00024
Swiss Giftliste 1
G-5964
Canada DSL/NDSL
NDSL
US TSCA
Listed
Austrailia AICS
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C4H7ClO2
Formula mass
122.56
Melting point, °C
-81
Boiling point, °C
103
Vapor density (air=1)
4.2
Critical temperature
304
Critical pressure
37.3
Density
1.08 g/cm3 (20 C)
Solubility in water
Insoluble
Refractive index
1.4013 (20 C)
Partition coefficient, pKow
1.51

Hazards and Protection.
Storage
Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Wear appropriate protective gloves, clothing and goggles.
Respirators
Wear positive pressure self-contained breathing apparatus (SCBA).
Small spills/leaks
Keep sparks, flames, and other sources of ignition away. Keep material out of water sources and sewers. Build dikes to contain flow as necessary. Attempt to stop leak if without undue personnel hazard. Use water spray to knock-down vapors.
Stability
Hydrolyzes readily in the presence of water or moist air.
Incompatibilities
Attacks many metals especially in humid atmosphere May react vigorously or explosively
Decomposition
May explode on heating. Decomposes on heating or on contact with acids producing toxic and corrosive fumes including chlorine and phosgene.

Fire.
Flash Point,°C
20 (closed cup)
Autoignition, °C
>500
Upper exp. limit, %
15
Lower exp. limit, %
4
Fire fighting
Isolate for 1/2 mile in all directions if tank car or truck is involved in fire.Keep unnecessary people away and isolate hazard area. Stay upwind and keep out of low areas. Wear self-contained (positive pressure if available) breathing apparatus and full protective clothing. For small fires, use dry chemical, carbon dioxide, water spray or foam. For large fires, use water spray, fog or foam. Do not get water inside container. Cool containers exposed to flame with water until well after fire is out. Withdraw immediately in case of rising sound from venting safety device or any discoloration of tank due to fire.
Fire potential
HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames.
Hazards
Extremely dangerous; this chemical has exploded while stored in refrigerator. Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Like other chlorides, when heated to decomposition or on contact with acids or acrid fumes, they evolve highly toxic chloride fumes. Reacts violently with phosgene. Unstable, avoid phosgene
Combustion products
Fire will produce irritating, corrosive and/or toxic gases.

Health.
Poison_Class
1
Exposure effects
   Ingestion
Ingestion may cause burns of the esophagus or gastrointestinal tract.
   Inhalation
The irritation may be only mild enough to cause cough and dyspnea, or may cause noncardiogenic pulmonary edema and lung tissue destruction.
   Skin
Dermal irritation, burns, and sensitization may occur.
   Eyes
See Inhalation.

First aid
 
   Ingestion
Emesis not recommended - inducing vomiting is not indicated due to this chemical's irritant properties. Dilution - following ingestion and/or prior to gastric evacuation, immediately dilute with 4 to 8 ounces (120 to 240 ml) of milk or water (not to exceed 15 ml/kg in a child). Gastric lavage/precautions
   Inhalation
Move patient to fresh air. Monitor for respiratory distress. If cough or difficulty breathing develops, evaluate for respiratory tract irritation, bronchitis, or pneumonitis. Administer oxygen and assist ventilation as required. Treat bronchospasm with beta2 agonist and corticosteroid aerosols.
   Skin
Remove contaminated clothing and wash exposed area thoroughly with soap and water. A physician should examine the area if irritation or pain persists. Treat dermal irritation or burns with standard topical therapy. Patients developing dermal hypersensitivity reactions may require treatment with systemic or topical corticosteroids or antihistamines.
   Eyes
Irrigate exposed eyes with copious amounts of tepid water for at least 15 minutes. If irritation, pain, swelling, lacrimation, or photophobia persist, the patient should be seen in a health care facility.

Transport.
UN number
2407
Response guide
Hazard class
6.1
PRTC
T
Packing Group
I
 
USCG CHRIS Code
PCF
 
Std. Transport #
4921252 4907628