Isopropylamine

  • 2-Aminopropane
  • 2-Propanamine
  • 1-Methylethylamine
  • sec-Propylamine
  • 2-Propylamine
  • Monoisopropylamine
Formula
(CH3)2CHNH2
Structure
Description
Clear, colorless liquid with an ammonia-like odor.
Uses
Solvent, intermediate in synthesis of rubber accelerators, pharmaceuticals, dyes, insecticides, bactericides, textile specialities, and surface-active agents, dehairing agent, solubilizer for 2,4-d acid.

Registry Numbers and Inventories.
CAS
75-31-0
EC (EINECS/ELINCS)
200-860-9
EC Index Number
612-007-00-1
EC Class
Extremely flammable; Irritant
R 12 36/37/38
S 16 26 29
RTECS
NT8400000
RTECS class
Tumorigen; Primary Irritant
UN (DOT)
1221
Merck
13,5229
Beilstein/Gmelin
605259
Beilstein Reference
4-04-00-00504
Swiss Giftliste 1
G-1092
Canada DSL/NDSL
DSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C3H9N
Formula mass
59.11
Melting point, °C
-101
Boiling point, °C
32.4
Vapor pressure, mmHg
580 (25 C)
Vapor density (air=1)
2.04
Saturation Concentration
60.5% (20 C)
Odor Threshold Odor threshold 0.504 mg/m3
Critical temperature
199
Critical pressure
44.8
Density
0.69 (g/cm3 (20 C)
Solubility in water
Miscible
Surface tension
16.8 g/s2 (25 C)
Refractive index
1.377 (20 C)
Dipole moment
1.19 D
pKa/pKb
3.37 (pKb)
Partition coefficient, pKow
0.26
Heat of vaporization
28.36 kJ/mol
Heat of combustion
-2345.5 kJ/mol

Hazards and Protection.
Storage
Keep away from heat, sparks, and flame. Keep away from sources of ignition. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Refrigerator (approx 4 C). Store in steel containers.
B2 E D1B
Handling
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use only in a well ventilated area. Ground and bond containers when transferring material. Do not breathe dust, vapor, mist, or gas. Do not get in eyes, on skin, or on clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Avoid contact with heat, sparks and flame. Do not ingest or inhale. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.
Small spills/leaks
Absorb spill with inert material, (e.g., dry sand or earth), then place into a chemical waste container. Clean up spills immediately, using the appropriate protective equipment. Remove all sources of ignition. Use a spark-proof tool. Provide ventilation. Do not get water inside containers. A vapor suppressing foam may be used to reduce vapors. Water spray may reduce vapor but may not prevent ignition in closed spaces.
Disposal code
5
Stability
Stable under normal temperatures and pressures.
Incompatibilities
Strong oxidizing agents, strong acids, acid chlorides, acid anhydrides, perchloryl fluoride, 1-chloro-1,3-epoxypropane, aldehydes, epoxides (e.g. butyl glycidyl ether), halogenated agents, mineral acids, organic acids, sodium hypochlorite, calcium hypochlorite, copper, aluminum, zinc, galvanized surfaces, peroxides.
Decomposition
Nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide, ammonia, nitric acid.

Fire.
Flash Point,°C
-37
Autoignition, °C
402
Upper exp. limit, %
10.4
Lower exp. limit, %
2.0
Fire fighting
Evacuate area and fight fire from a safe distance. As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Approach fire from upwind to avoid hazardous vapors and toxic decomposition products. Extinguish with water spray, dry chemical, alcohol resistant foam, or carbon dioxide. Water may be ineffective because it will not cool material below its flash point.
Fire potential
Extremely flammable liquid and vapor. Vapor may cause flash fire.
Hazards
Burning isopropylamine is difficult to control because of the ease of reignition of the vapor. Vapors are heavier than air and may travel to a source of ignition and flash back. Containers may explode.
Combustion products
Toxic oxides of nitrogen may form in fire.
Health
3
 
Flammability
4
 
 
Reactivity
0
 

Health.
Exposure limit(s)
OSHA PEL: TWA 5 ppm (12 mg/m3) NIOSH REL: See Appendix D NIOSH IDLH: 750 ppm
Poison_Class
3
Exposure effects
Prolonged or repeated skin contact may cause dermatitis.
   Ingestion
Harmful if swallowed. Causes gastrointestinal tract burns. May cause central nervous system effects.
   Inhalation
Harmful if swallowed. Causes gastrointestinal tract burns. May cause central nervous system effects.
   Skin
Harmful if absorbed through the skin. Causes severe skin irritation and burns.
   Eyes
Low vapor concentrations may cause a temporary visual disturbance known as 'blue haze' or 'halo vision'. Causes eye irritation and burns. May cause tearing, conjunctivitis and corneal edema when vapor is absorbed into the tissue of the eye. Direct contact with liquid may cause blindness or permanent eye damage.

First aid
 
   Ingestion
Do NOT induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
   Inhalation
Remove from exposure to fresh air immediately. If breathing is difficult, give oxygen. Get medical aid. DO NOT use mouth-to-mouth respiration. If breathing has ceased apply artificial respiration using oxygen and a suitable mechanical device such as a bag and a mask.
   Skin
Get medical aid immediately. Immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Discard contaminated clothing in a manner which limits further exposure. Destroy contaminated shoes.
   Eyes
Get medical aid immediately. Do NOT allow victim to rub or keep eyes closed. Extensive irrigation is required (at least 30 minutes).

Transport.
UN number
1221
Response guide
Hazard class
3
Packing Group
I
 
USCG CHRIS Code
IPP
 
7 Aliphatic amines
HS Code
2921 19 30
 
Std. Transport #
4931311
 
IMO Chemical Code
17
IMO Pollution Category
C
IMO Hazard code
S/P