Isosorbide dinitrate

  • Cardis
  • Carvanil
  • Carvasin
  • Cedocard
  • Claodical
  • Corosorbide
Formula
C6H8N2O8
Structure
Description
A crystalline solid.
Uses
Medication.

Registry Numbers and Inventories.
CAS
87-33-2
EC (EINECS/ELINCS)
201-740-9
RTECS
LZ4385000
RTECS class
Drug; Mutagen; Reproductive Effector; Human Data; Primary Irritant
UN (DOT)
2907
Merck
12,5245
Beilstein/Gmelin
88225
Beilstein Reference
4-19-00-00998
Canada DSL/NDSL
DSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed

Properties.
Formula
C6H8N2O8
Formula mass
236.14
Melting point, °C
70
Solubility in water
Insoluble

Hazards and Protection.
Storage
Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Respirators
Use NIOSH/MSHA approved respirator appropriate for exposure of concern.
Small spills/leaks
Keep sparks, flames, and other sources of ignition away. Keep material out of water sources and sewers.
Stability
No data.
Incompatibilities
If mixed with reducing agents, including hydrides, sulfides and nitrides, they may begin a vigorous reaction that culminates in a detonation.

Fire.
Fire fighting
Solid streams of water may spread fire. Use water in flooding quantities as fog. Use dry chemical, graphite, or dry earth.
Fire potential
Flammable/combustible material.
Hazards
May be ignited by friction, heat, sparks or flames. Some may burn rapidly with flare burning effect. Powders, dusts, shavings, borings, turnings or cuttings may explode or burn with explosive violence. Substance may be transported in a molten form. May re-ignite after fire is extinguished.

Health.
Exposure effects
Abnormally low blood pressure is common. Low heart rate may occur in predisposed patients; reflex rapid heart rate may occur. Death occurs secondary to circulatory collapse or respiratory failure. With therapeutic use - 1. Headache and dizziness are common, even after administration of therapeutic doses. Acute wernicke's encephalopathy from intravenous infusions may be precipitated by ethanol and propylene glycol diluents. In male rats, a dominant lethal test showed no effect on male fertility; interstitial cell tumors of rat testes were induced after nitroglycerin exposure. Results on teratogenicity in rats are conflicting.
   Ingestion
Nausea, vomiting, colicky pain, and diarrhea may occur.
   Eyes
LOSS OF VISION - A transient loss of vision reportedly occurred before acute toxic effects from nitroglycerin exposure. Constriction of the pupil and corneal damage occurred after intravenous exposure.

First aid
 
   Ingestion
Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control center for advice about whether to induce vomiting. If possible, do not leave individual unattended.
   Inhalation
If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.
   Skin
Remove contaminated clothing. Wash exposed area with soap and water. If symptoms persist, seek medical attention. Launder clothing before reuse.
   Eyes
If symptoms develop, immediately move individual away from exposure and into fresh air. Flush eyes gently with water for at least 15 minutes while holding eyelids apart; seek immediate medical attention.

Transport.
UN number
2907
Response guide
Std. Transport #
4917431