Jervine

  • Jervin
  • 17,23-Epoxy-3-hydroxyveratraman-11-one, (3b,23b)-
Formula
C27H39NO3
Structure
Description
Needles from methanol + water.

Registry Numbers and Inventories.
CAS
469-59-0
EC (EINECS/ELINCS)
207-417-9
RTECS
WG9700000
RTECS class
Reproductive Effector; Natural Product
Merck
12,5277
Beilstein/Gmelin
59109
Beilstein Reference
4-27-00-03590

Properties.
Formula
C27H39NO3
Formula mass
425.61
Melting point, °C
247 - 248
Solubility in water
Insoluble
pKa/pKb
3.99 (pKb)

Hazards and Protection.
Storage
Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Respirators
Use NIOSH/MSHA approved respirator appropriate for exposure of concern.
Small spills/leaks
Evacuate area and ventilate. Wear protective equipment. If required, use an inert absrobent. Sweep up and place in an appropriate container for disposal. Wash contaminated surfaces.
Stability
No data.
Incompatibilities
Strong oxidizing agents.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.

Health.
Exposure effects
salivation, muscular weakness, and syncope may occur. Coma may occur in severe cases. Headache, aphasia, and seizures are uncommon effects of intoxication.
   Ingestion
Severe nausea and vomiting with epigastric and substernal pain may occur.
   Inhalation
Dyspnea may occur.
   Skin
Sweating has been reported.

First aid
 
   Ingestion
Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control center for advice about whether to induce vomiting. If possible, do not leave individual unattended.
   Inhalation
If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.
   Skin
Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
   Eyes
Irrigate exposed eyes with copious amounts of tepid water for at least 15 minutes. If irritation, pain, swelling, lacrimation, or photophobia persist, the patient should be seen in a health care facility.

Transport.