Kanamycin A sulfate

  • Kanamytrex
  • D-Streptamine, O-3-amino-3-deoxy-a-D-glucopyranosyl-(1-> 6)-O-[6-amino-6-deoxy-a-D-glucopyranosyl-(1-> 4)]-2-deoxy-, sulfate (1:1) (salt)
  • Kanamycin A monosulfat
  • Ophtalmokalixan
  • Resistomycin
  • Enterokanacin
Formula
C18H36N4O11.H2SO4
Structure
Description
odorless colorless to white powder
Uses
Antibiotic.

Registry Numbers and Inventories.
CAS
25389-94-0
EC (EINECS/ELINCS)
246-933-9
RTECS
NZ3225030
RTECS class
Drug; Reproductive Effector; Human Data; Natural Product
Beilstein/Gmelin
3874279
Beilstein Reference
4-18-00-07631
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C18H36N4O11*H2O4S
Formula mass
582.57

Hazards and Protection.
Storage
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
Handling
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use only in a well ventilated area. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Do not breathe dust, vapor, mist, or gas. Keep container tightly closed. Avoid ingestion and inhalation.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.
Small spills/leaks
Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, using the appropriate protective equipment. Avoid generating dusty conditions. Provide ventilation.
Stability
Stable under normal temperatures and pressures.
Incompatibilities
Strong oxidizing agents.
Decomposition
Carbon monoxide, oxides of nitrogen, oxides of sulfur, irritating and toxic fumes and gases, carbon dioxide.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. This material in sufficient quantity and reduced particle size is capable of creating a dust explosion. Extinguishing media: Use extinguishing media most appropriate for the surrounding fire. In case of fire use water spray, dry chemical, carbon dioxide, or appropriate foam.
Health
2
 
Flammability
0
 
 
Reactivity
0
 

Health.
Exposure effects
Prolonged or repeated skin contact may cause defatting and dermatitis. Animal studies have reported that fetal effects/abnormalities may occur when maternal toxicity is seen. Chronic exposure may cause kidney damage.
   Ingestion
May cause gastrointestinal irritation with nausea, vomiting and diarrhea. May cause auditory damage with possible loss of hearing. May cause neuromuscular paralysis, intestinal malabsorption, and superinfections.
   Inhalation
May cause effects similar to those described for ingestion.
   Skin
May cause skin irritation. May cause skin sensitization, an allergic reaction, which becomes evident upon re-exposure to this material. May be absorbed through the skin.
   Eyes
Exposure to solid may cause pain and redness.

First aid
 
   Ingestion
If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
   Inhalation
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
   Skin
Get medical aid. Immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
   Eyes
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Transport.