- (+/-)-2-(o-Chlorophenyl)-2-(methylamino)cyclohexanone hydrochloride
- CI 581
Colorless to white crystals.
Medication. Selective NMDA glutamate receptor antagonist; veterinary anesthetic.
Registry Numbers and Inventories.
22 36/37/38 40
Drug; Mutagen; Reproductive Effector; Human Data
Melting point, °C
262 - 263
Solubility in water
0.2 g/mL (20 C)
Hazards and Protection.
Keep tightly closed. Store at 2-8 C
Compatible chemical-resistant gloves. Chemical safety goggles.
Government approved respirator.
Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.
Stable at normal temperatures and pressures.
When heated to decomposition, the material emits fumes of HCl and NOx.
Extinguish using Water spray. Carbon dioxide, dry chemical powder, or appropriate foam. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
Emits toxic fumes under fire conditions.
Sedation and respiratory depression have been reported after overdose in medical settings. Patients usually awaken within a few hours, although sedation lasting 24 hours has been described. Ketamine has become a drug of abuse. Common effects include tachycardia, altered mental status, anxiety, palpitations, slurred speech hallucinations, nystagmus, mydriasis, mild hypertension and chest pain. Confusion, vomiting and memory loss are less common. Rarely seizures, polyneuropathy, or respiratory arrest may occur. Death is rare following ketamine abuse or overdose.
Nausea and vomiting have been reported.
Respiratory depression, apnea, and respiratory arrest may occur. Ketamine may produce bronchodilation and increased salivary and tracheobronchial secretions.
May be harmful if absorbed through the skin.
Temporary loss of vision or blurred vision may be noted.
Benzodiazepines or droperidol and minimization of sensory stimuli may reduce the incidence of psychotomimetic effects of ketamine. Administer oxygen and manage airway as clinically indicated.
Remove contaminated clothing and wash exposed area thoroughly with soap and water. A physician may need to examine the area if irritation or pain persists.
Irrigate eye for at least 20 minutes with water or saline. If irritation persists, seek medical attention.