(L)-Ephedrine

  • Biophedrin
  • Eciphin
  • Efedrin
  • Ephedral
  • Ephedrate
  • Ephedremal
Formula
C10H15NO
Structure
Description
Waxy white to off-white solid, crystals or granules.
Uses
Optically pure amines used as resolving agents include alkaloids such as ephedrine. Medication.

Registry Numbers and Inventories.
CAS
299-42-3
EC (EINECS/ELINCS)
206-080-5
EC Index Number
614-023-00-4
EC Class
Harmful
RTECS
KB0700000
RTECS class
Drug; Reproductive Effector; Human Data; Natural Product
Beilstein/Gmelin
972533
Canada DSL/NDSL
NDSL
US TSCA
Listed
Austrailia AICS
Listed
Korea ECL
Listed

Properties.
Formula
C10H15NO
Formula mass
165.26
Melting point, °C
217 - 218
Boiling point, °C
132 (3 torr)
Density
1.124 g/cm3 (20 C)
Solubility in water
50 g/L

Hazards and Protection.
Storage
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Refrigerator (approx 4 C). Store protected from moisture. Store protected from light.
Handling
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Store protected from light.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks
Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, using the appropriate protective equipment. Avoid generating dusty conditions. Provide ventilation.
Stability
Stable under normal temperatures and pressures.
Incompatibilities
Moisture, oxidizing agents.
Decomposition
Nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide, nitrogen.

Fire.
Flash Point,°C
85
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Dusts at sufficient concentrations can form explosive mixtures with air. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Runoff from fire control or dilution water may cause pollution. To extinguish fire, use water, dry chemical, chemical foam, or alcohol-resistant foam. Use agent most appropriate to extinguish fire.
Health
1
 
Flammability
2
 
 
Reactivity
0
 

Health.
Exposure effects
Elevated blood pressure may occur, accompanied by rapid heart rate may occur. Low heart rate has been reported following overdoses of phenylpropanolamine and as a late presentation following norepinephrine depletion. Increased temperature may occur. anxiety, nervousness, insomnia, muscle tremor, seizures, altered mental status and cerebral hemorrhage and ischemia may be noted. Toxic psychosis may develop following acute overdoses or abuse of sympathomimetics.
   Ingestion
May cause irritation of the digestive tract. May be harmful if swallowed.
   Inhalation
May cause respiratory tract irritation.
   Skin
May cause skin irritation.
   Eyes
May cause eye irritation.

First aid
 
   Ingestion
Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
   Inhalation
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
   Skin
Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
   Eyes
Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Transport.