L-Epinephrine

  • L-Adrenaline
  • Hypernephrin
  • Levoepinephrine
  • Vasoconstrictine
  • 3,4-Dihydroxy-a-((methylamino)methyl)benzyl alcohol
  • 1,2-Benzenediol, 4-[(1R)-1-hydroxy-2-(methylamino)ethyl]-
Formula
C9H13NO3
Structure
Description
White to nearly-white microcrystalline powder or granules. Odorless. Aqueous solutions are slightly alkaline. Slightly bitter, numbing taste.
Uses
Epinephrine may be applied topically to control superficial bleeding from arterioles or capillaries in the skin, mucous membrane, or other tissues. Bleeding from larger vessels is not controllable by topical application of epinephrine.

Registry Numbers and Inventories.
CAS
51-43-4
EC (EINECS/ELINCS)
200-098-7
R 23/24/25
S 22 36/37 45
RTECS
DO2625000
RTECS class
Drug; Mutagen; Reproductive Effector; Human Data
UN (DOT)
2811
Merck
13,3650
Beilstein/Gmelin
2368277
Beilstein Reference
4-13-00-02927
RCRA
P042
Canada DSL/NDSL
DSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed

Properties.
Formula
C9H13NO3
Formula mass
183.21
Melting point, °C
211-212
Boiling point, °C
346
Vapor pressure, mmHg
3E-15
Critical temperature
529
Critical pressure
55.0
Solubility in water
Very soluble
pKa/pKb
4.84 (pKb)
Partition coefficient, pKow
0.28

Hazards and Protection.
Storage
Refrigerator (approx 4 C).
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Eyes: Wear safety glasses and chemical goggles if splashing is possible. Skin: Wear appropriate protective gloves and clothing to prevent skin exposure. Clothing: Wear appropriate protective clothing to minimize contact with skin.
Respirators
Wear a NIOSH/MSHA or European Standard EN 149 approved full-facepiece airline respirator in the positive pressure mode with emergency escape provisions.
Small spills/leaks
Sweep up, then place into a suitable container for disposal.
Stability
Stable under normal temperatures and pressures.
Incompatibilities
Acids - acid chlorides - acid anhydrides - oxidizing agents - light.
Decomposition
Nitrogen oxides, carbon monoxide, carbon dioxide, nitrogen.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. To extinguish fire, use water, dry chemical, chemical foam, or alcohol-resistant foam.
Fire potential
This material is probably combustible.
Hazards
Contact with metals may evolve flammable hydrogen gas.
Combustion products
Fire may produce irritating, corrosive and/or toxic gases.

Health.
Exposure effects
anxiety, diaphoresis, palpitations, tremor, and numbness and tingling of the extremities may occur.
   Ingestion
See Inhalation.
   Inhalation
Pulmonary edema and cyanosis may occur.
   Skin
Pallor, sweating and erythema have been reported following parenteral sympathomimetics. Injection site reactions from either subcutaneous intentional (skin pop) or unintentional injections may result in edema, cellulitis, and local ischemia.
   Eyes
MYDRIASIS has been seen following overdoses.

First aid
 
   Ingestion
Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
   Inhalation
Remove from exposure to fresh air immediately.
   Skin
Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
   Eyes
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids.

Transport.
UN number
2811
Response guide
Hazard class
6.1
Packing Group
I; II; III
 
USCG CHRIS Code
EPH