L-(-)-Menthol

  • L-p-Menthan-3-ol
  • (1R,2S,5R)-(-)-Menthol
  • (-)-Menthyl alcohol
  • (1R-(1-alpha,2-beta,5-alpha))-5-Methyl-2-(1-methylethyl)cyclohexanol
Formula
C10H20O
Structure
Description
Crystals or granules. Peppermint odor.
Uses
Medication: topical antipruritic, medication (vet): has been used as a mild local anesthetic, antiseptic & internally as a carminative & gastric sedative menthol.

Registry Numbers and Inventories.
CAS
2216-51-5
EC (EINECS/ELINCS)
218-690-9
EC Class
irritant
R 37/38 41
S 26 36/37/39
RTECS
OT0700000
RTECS class
Mutagen; Natural Product; Primary Irritant
Merck
13,5861
Beilstein/Gmelin
1902293
Beilstein Reference
4-06-00-00150
Canada DSL/NDSL
DSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed

Properties.
Formula
C10H20O
Formula mass
156.27
Melting point, °C
41 - 44
Boiling point, °C
212
Vapor pressure, mmHg
0.8 (25 C)
Density
0.89 g/cm3 (15 C)
Solubility in water
0.4 g/L
Viscosity
7.37 cp (52 C)
Surface tension
27.17 g/s2 (60 C)
Refractive index
1.46 (20 C)
Partition coefficient, pKow
3.3
Heat of fusion
13.60 kJ/mol
Heat of vaporization
56.92 kJ/mol
Heat of combustion
-6319 kJ/mol

Hazards and Protection.
Storage
Store in a tightly closed container. Store in a cool, dry area away from incompatible substances.
Handling
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Do not get in eyes, on skin, or on clothing. Avoid ingestion and inhalation. Use with adequate ventilation. Use only in a chemical fume hood.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.
Small spills/leaks
Wash area with soap and water. Clean up spills immediately, using the appropriate protective equipment. Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions. Provide ventilation.
Stability
Stable at room temperature in closed containers under normal storage and handling conditions.
Incompatibilities
Strong oxidizing agents, phenols, potassium permanganate, chromium trioxide, chloral hydrate, thymol, pyrogallol, resorcinol, camphor, butylchloral hydrate, betanaphthol, exalgine.
Decomposition
Carbon monoxide, carbon dioxide, acrid smoke and fumes.

Fire.
Flash Point,°C
96
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing media: Water may be ineffective. In case of fire use water spray, dry chemical, carbon dioxide, or appropriate foam.
Health
2
 
Flammability
1
 
 
Reactivity
0
 

Health.
Poison_Class
4 (Substances and products that must be considered harmful)
Exposure effects
Effects may be delayed.
   Ingestion
May cause gastrointestinal irritation with nausea, vomiting and diarrhea.
   Inhalation
Causes respiratory tract irritation. Can produce delayed pulmonary edema.
   Skin
Causes skin irritation.
   Eyes
Causes eye irritation. May cause conjunctivitis and corneal inflammation.

First aid
 
   Ingestion
Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
   Inhalation
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
   Skin
Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
   Eyes
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Transport.
20. Alcohols. Glycols
HS Code
2906 11 00