L-Phenylephrine hydrochloride

  • Isophrin hydrochloride
  • neo-Synephrine hydrochloride
  • meta-Synephrine hydrochloride
  • R-(-)-m-Synephrine hydrochloride
  • l-m-Hydroxy-a-[(methylamino)methyl]benzyl alcohol hydrochloride
  • Benzenemethanol, 3-hydroxy-a-[(methylamino)methyl]-, hydrochloride, (aR)-
Formula
C9H14ClNO2
Structure
Description
Odorless white microcrystalline powder. Bitter taste.
Uses
Adrenergic drug.

Registry Numbers and Inventories.
CAS
61-76-7
EC (EINECS/ELINCS)
200-517-3
R 22 36/37/38
S 26 36/37/39
RTECS
DO7525000
RTECS class
Tumorigen; Drug; Mutagen; Reproductive Effector; Human Data
UN (DOT)
1760
Merck
12,7440
Beilstein/Gmelin
4158948
Beilstein Reference
3-13-00-02236
Canada DSL/NDSL
DSL
US TSCA
Listed
Austrailia AICS
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C9H13NO2*ClH
Formula mass
203.67
Melting point, °C
138 - 141

Hazards and Protection.
Storage
Store in a cool, dry, well-ventilated area away from incompatible substances. Keep containers tightly closed.
Handling
Wash thoroughly after handling. Use only in a well ventilated area. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks
Clean up spills immediately, using the appropriate protective equipment. Sweep up or absorb material, then place into a suitable clean, dry, closed container for disposal. Avoid generating dusty conditions. Provide ventilation.
Stability
Stable under normal temperatures and pressures.
Incompatibilities
Oxidizing agents, acids, acid chlorides, acid anhydrides.
Decomposition
Hydrogen chloride, nitrogen oxides, carbon monoxide, carbon dioxide.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing media: Use agent most appropriate to extinguish fire. In case of fire use water spray, dry chemical, carbon dioxide, or appropriate foam.
Fire potential
This material is probably combustible.
Hazards
Contact with metals may evolve flammable hydrogen gas.
Combustion products
Fire may produce irritating, corrosive and/or toxic gases.
Health
2
 
Flammability
0
 
 
Reactivity
0
 

Health.
Exposure effects
   Ingestion
Harmful if swallowed. Causes gastrointestinal irritation with nausea, vomiting and diarrhea.
   Inhalation
May cause respiratory tract irritation.
   Skin
May cause skin irritation.
   Eyes
May cause eye irritation.

First aid
 
   Ingestion
If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
   Inhalation
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
   Skin
Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
   Eyes
Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Transport.
UN number
1760
Response guide
Hazard class
8
Packing Group
I; II; III