L-Proline

  • 2-Pyrrolidinecarboxylic acid
  • FEMA number 3319
  • Pro (Iupac abbreviation)
  • Proline
  • (S)-Proline
Formula
C5H9NO2
Structure
Description
Flat needles from alcohol-ether; prisms from water.
Uses
Nutrient &or dietary supplement food additive.

Registry Numbers and Inventories.
CAS
147-85-3
EC (EINECS/ELINCS)
205-702-2
RTECS
TW3584000
RTECS class
Mutagen
Merck
12,7963
Beilstein/Gmelin
80810
Beilstein Reference
5-22-01-00031
Canada DSL/NDSL
DSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C5H9NO2
Formula mass
115.13
Melting point, °C
149
Boiling point, °C
245
Decomposition point, °C
220-222
Vapor pressure, mmHg
0.006 (25 C)
Critical temperature
471
Critical pressure
50.1
Density
1.35 g/cm3 (25 C)
Solubility in water
127 g/100 ml (0 C)
pKa/pKb
2.35 (pKa)
Partition coefficient, pKow
-2.37
Heat of combustion
-2746 kJ/mol

Hazards and Protection.
Storage
Store in a cool, dry, well-ventilated area away from incompatible substances.
Handling
Wash thoroughly after handling. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with skin and eyes. Keep container tightly closed. Avoid ingestion and inhalation.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks
Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions. Provide ventilation.
Disposal code
31
Stability
Stable under normal temperatures and pressures.
Incompatibilities
Strong oxidizers.
Decomposition
Nitrogen oxides, carbon monoxide, carbon dioxide.

Fire.
Flash Point,°C
106
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Dusts at sufficient concentrations can form explosive mixtures with air. Combustion generates toxic fumes. Extinguishing media: For small fires, use water spray, dry chemical, carbon dioxide or chemical foam. Use agent most appropriate to extinguish fire.

Health.
Exposure effects
May cause irritation of the eyes, skin and respiratory tract. Expected to be a low ingestion hazard.
   Ingestion
The toxicological properties of this substance have not been fully investigated.
   Inhalation
The toxicological properties of this substance have not been fully investigated.
   Skin
Low hazard for usual industrial handling.
   Eyes
No information regarding eye irritation and other potential effects was found. Contact may cause transient eye irritation.

First aid
 
   Ingestion
If victim is conscious and alert, give 2-4 cupfuls of milk or water. Get medical aid immediately.
   Inhalation
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
   Skin
Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Get medical aid if irritation develops or persists.
   Eyes
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Transport.
HS Code
2933 99 90