(L)-Propoxyphene

  • Levopropoxyphene
  • (R)-alpha-Propanoate
  • (-)-4-(Dimethylamino)-3-methyl-1,2-diphenyl-2-(propionyloxy)butane
  • alpha-l-4-dimethylamino-3-methyl-1,2-diphenyl-2-butanol propionate
Formula
C22H29NO2
Structure
Description
Crystals from petroleum ether.
Uses
Medication (vet).

Registry Numbers and Inventories.
CAS
2338-37-6
Merck
12,5495
Beilstein/Gmelin
3219810
Beilstein Reference
4-13-00-02221

Properties.
Formula
C22H29NO2
Formula mass
339.48
Melting point, °C
75 - 76
Solubility in water
Insoluble

Hazards and Protection.
Storage
Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Respirators
Use NIOSH/MSHA approved respirator appropriate for exposure of concern.
Small spills/leaks
Evacuate area and ventilate. Wear protective equipment. If required, use an inert absrobent. Sweep up and place in an appropriate container for disposal. Wash contaminated surfaces.
Stability
Permits more stable liquidand tablet dosage forms napsylate.
Incompatibilities
Strong oxidizing agents.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.

Health.
Exposure effects
Respiratory depression, abnormally low blood pressure, mild reduced body temperature, rapid heart rate or low heart rate may develop. mild CNS depression, drowsiness, headache, and stupor are common. Seizures or coma may develop with severe poisoning. A neonatal withdrawal syndrome has been reported in infants born to mothers taking high daily doses of propoxyphene.
   Ingestion
Nausea, vomiting, or abdominal pain may be noted.
   Inhalation
Respiratory depression is common. Sudden respiratory arrest can occur within 15 to 30 minutes. Pulmonary edema may occur in severe cases.
   Eyes
Miotic pupils are common.

First aid
 
   Ingestion
Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control center for advice about whether to induce vomiting. If possible, do not leave individual unattended.
   Inhalation
If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.
   Skin
Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
   Eyes
If symptoms develop, immediately move individual away from exposure and into fresh air. Flush eyes gently with water for at least 15 minutes while holding eyelids apart; seek immediate medical attention.

Transport.