LSD

  • Lysergide
  • N,N-Diethyllysergamide
  • D-Lysergic acid diethylamide
  • Ergoline-8-carboxamide, 9,10-didehydro-N,N-diethyl-6-methyl-, (8b)-
Formula
C20H25N3O
Structure
Description
Prismatic crystals (from benzene). Tasteless and odorless.
Uses
In biochemical research as antagonist to serotonin.

Registry Numbers and Inventories.
CAS
50-37-3
EC (EINECS/ELINCS)
200-033-2
RTECS
KE4100000
RTECS class
Drug; Mutagen; Reproductive Effector; Human Data
Merck
12,5665
Beilstein/Gmelin
94179
Beilstein Reference
4-25-00-00939

Properties.
Formula
C20H25N3O
Formula mass
323.44
Melting point, °C
82
Solubility in water
Insoluble
pKa/pKb
6.53 (pKb)
Partition coefficient, pKow
1.46

Hazards and Protection.
Storage
Stable when stored at or below room temperature and protected from direct sunlight or other sources of ultraviolet radiation.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Respirators
Wear a NIOSH-approved half face respirator equipped with a combination filter cartridge, i.e. organic vapor/acid gas/HEPA (specific for organic vapors, HCl, acid gas, SO2 and a high efficiency particulate filter).
Small spills/leaks
If you spill this chemical, you should dampen the solid spill material with water, then transfer the dampened material to a suitable container. Use absorbent paper dampened with water to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Wash all contaminated surfaces with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.
Stability
No data.
Incompatibilities
Organic amides/imides react with azo and diazo compounds to generate toxic gases Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents Can react as acids.

Fire.
Fire fighting
Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher.

Health.
Exposure effects
Elevated blood pressure or abnormally low blood pressure, rapid heart rate, rapid breathing, and elevated body temperature may occur. an acutely altered mental status characterized by restlessness, acute anxiety, behavioral changes, depersonalization, tremors and incoordination may occur. Sympathomimetic symptoms may predominate initially. Seizures, muscle weakness, and ataxia are rare adverse effects.
   Inhalation
Tachypnea and bronchoconstriction may occur at high doses.
   Eyes
Mydriasis is frequently reported. Tearing may also occur. Impaired perception of color and other visual functions, persistent or recurrent visual illusions and halos around objects have been reported.

First aid
 
   Ingestion
If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. MMEDIATELY transport the victim to a hospital.
   Inhalation
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used.
   Skin
IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.
   Eyes
First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

Transport.