Laetrile

  • Amygdalin
  • R-Amygdalin
  • Amygdaloside
  • (R)-alpha-((6-o-beta-D-Glucopyranosyl-beta-D-glucopyranosyl)oxy)benzeneacetonitrile
  • Mandelonitrile-beta-gentiobioside
  • Vitamin B-17
Formula
C20H27NO11
Structure
Description
Odorless, white powder.
Uses
Studied extensively as a potential anti-cancer drug. Sold as a dietary supplement although no anti-cancer activity has been identified.

Registry Numbers and Inventories.
CAS
29883-15-6
EC (EINECS/ELINCS)
249-925-3
S 22 36/37
RTECS
OO8450000
RTECS class
Drug; Mutagen; Reproductive Effector; Human Data
Merck
13,701
Beilstein/Gmelin
66856
Beilstein Reference
5-17-08-00118
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Korea ECL
Listed

Properties.
Formula
C20H27NO11
Formula mass
457.43
Melting point, °C
226
Solubility in water
83 g/L

Hazards and Protection.
Storage
Store in a cool, dry place. Store in a tightly closed container.
Handling
Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks
Vacuum or sweep up material and place into a suitable disposal container.
Stability
No data.
Incompatibilities
Strong oxidizing agents, strong acids, strong bases.
Decomposition
Nitrogen oxides, carbon monoxide, carbon dioxide.

Fire.
Fire fighting
Containers can build up pressure if exposed to heat and/or fire. In case of fire use water spray, dry chemical, carbon dioxide, or chemical foam.

Health.
Exposure effects
Headaches, dizziness, lightheadedness, disorientation, irritability, unresponsiveness, lethargy, stupor, weakness, paralysis, areflexia, syncope coma, and seizures may follow gastrointestinal symptoms. Chronic consumption of plants containing high concentrations of cyanogenic glycosides has been associated with polyneuropathy which include optic atrophy, nerve deafness, spastic paraparesis, ataxia, clonus and peripheral neuropathy.
   Ingestion
Harmful if swallowed.
   Inhalation
May cause respiratory tract irritation.
   Skin
May cause skin irritation.
   Eyes
May cause eye irritation.

First aid
 
   Ingestion
Get medical aid. Wash mouth out with water.
   Inhalation
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
   Skin
Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
   Eyes
Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Transport.