Lapachol

  • Natural Yellow16
  • 2-Hydroxy-3-(3-methyl-2-butenyl)-1,4-naphthoquinone
  • C.I. 75490
Formula
C15H14O3
Structure
Description
Tasteless, intense yellow powder.Natural product with anti-tumor activity.
Uses
Naphtoquinone obtained from a natural source.

Registry Numbers and Inventories.
CAS
84-79-7
EC (EINECS/ELINCS)
201-563-7
20/21/22 36/37/38
RTECS
QL8750000
RTECS class
Drug; Reproductive Effector; Natural Product
UN (DOT)
2811
Merck
12,5376
Beilstein/Gmelin
2051889
Beilstein Reference
4-08-00-02487

Properties.
Formula
C15H14O3
Formula mass
242.27
Melting point, °C
140
Boiling point, °C
390
Vapor pressure, mmHg
9E-7 (25 C)
Solubility in water
Insoluble
pKa/pKb
5.01 (pKa)
Heat of vaporization
67.5 kJ/mol

Hazards and Protection.
Storage
Keep tightly closed. Store in a cool dry place.
Protection
Wear appropriate government approved respirator, chemical-resistant gloves, safety goggles, other protective clothing.
Respirators
Wear positive pressure self-contained breathing apparatus (SCBA).
Small spills/leaks
Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.
Incompatibilities
Strong oxidizing agents.
Decomposition
Carbon monoxide, Carbon dioxide.

Fire.
Flash Point,°C
204
Fire fighting
Extinguish using Water spray. Carbon dioxide, dry chemical powder, or appropriate foam. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
Fire potential
Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes.
Hazards
Emits toxic fumes under fire conditions.
Combustion products
Fire may produce irritating, corrosive and/or toxic gases.

Health.
Exposure effects
Harmful by inhalation, in contact with skin and if swallowed. Irritating to eyes, respiratory system and skin.
   Ingestion
See Inhalation.
   Inhalation
TOXIC; inhalation, ingestion, or skin contact with material may cause severe injury or death. Effects of contact or inhalation may be delayed.
   Skin
Contact with molten substance may cause severe burns to skin and eyes. See Inhalation.
   Eyes
See Inhalation.

First aid
 
   Ingestion
If swallowed, wash out mouth with water provided person is conscious. Call a physician.
   Inhalation
If inhaled, remove to fresh air. If not breathing give artificial respiration. If breathing is difficult, give oxygen.
   Skin
Remove and isolate contaminated clothing and shoes. Immediately flush with running water for at least 20 minutes. For minor skin contact, avoid spreading material on unaffected skin.
   Eyes
Immediately flush with running water for at least 20 minutes.

Transport.
UN number
2811
Response guide
Hazard class
6.1
Packing Group
III