Leurosine

  • Vinleurosine
  • NSC 528004
  • 4'-Deoxy-3',4'-epoxy-, (3'-alpha,4'-alpha)vincaleukoblastine
Formula
C46H56N4O9
Uses
Medication.

Registry Numbers and Inventories.
CAS
23360-92-1
RTECS
OH6370000
RTECS class
Drug
Beilstein/Gmelin
79636
Beilstein Reference
4-27-00-09622

Properties.
Formula
C46H56N4O9
Formula mass
809.06
Solubility in water
Insoluble
pKa/pKb
11.36 (pKa)

Hazards and Protection.

Fire.

Health.
Exposure effects
No specific evaluation of this chemical was found. However many chemicals cause irritation of the eyes, skin, and respiratory tract. In severe cases respiratory tract irritation can progress to ARDS/acute lung injury which may be delayed in onset for up to 24 to 72 hours in some cases. Irritation or burns of the esophagus or gastrointestinal tract are also possible if caustic or irritant chemicals are ingested.

First aid
 
   Ingestion
Consider gastric lavage after ingestion of a potentially life-threatening amount of poison if it can be performed soon after ingestion (generally within 1 hour). Administer charcoal as a slurry 240 mL water/30 g charcoal). Usual dose: 25 to 100 g in adults/adolescents, 25 to 50 g in children (1 to 12 years), and 1 g/kg in infants less than 1 year old. Immediate dilution with milk or water may be of benefit in caustic or irritant chemical ingestions.
   Inhalation
Move patient to fresh air. Monitor for respiratory distress. If cough or difficulty breathing develops, evaluate for respiratory tract irritation bronchitis, or pneumonitis. Administer oxygen and assist ventilation as required. Treat bronchospasm with inhaled beta2 agonist and oral or parenteral corticosteroids.
   Skin
Remove contaminated clothing and wash exposed area thoroughly with soap and water. A physician may need to examine the area if irritation or pain persists.
   Eyes
Irrigate exposed eyes with copious amounts of room temperature water for at least 15 minutes. If irritation, pain, swelling, lacrimation, or photophobia persist, the patient should be seen in a health care facility.

Transport.