Levodopa

  • 3-(3,4-Dihydroxyphenyl)-L-alanine
  • L-DOPA
Formula
C9H11NO4
Structure
Description
White to beige powder.
Uses
Medication.

Registry Numbers and Inventories.
CAS
59-92-7
EC (EINECS/ELINCS)
200-445-2
S 22 36/37
RTECS
AY5600000
RTECS class
Tumorigen; Drug; Mutagen; Reproductive Effector; Human Data
Merck
13,5485
Beilstein/Gmelin
2215169
Beilstein Reference
4-14-00-02492
Canada DSL/NDSL
NDSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C9H11NO4
Formula mass
197.19
Melting point, °C
276-278
Density
1.515 g/cm3
Solubility in water
1.6 g/L
Partition coefficient, pKow
-3.4

Hazards and Protection.
Storage
Store in a cool, dry place. Keep container closed when not in use. Absorbs oxygen from the air and will darken upon exposure. Store protected from light.
Handling
Wash thoroughly after handling. Use with adequate ventilation. Avoid contact with skin and eyes. Avoid ingestion and inhalation.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks
Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, using the appropriate protective equipment. Avoid generating dusty conditions.
Stability
Stable under normal temperatures and pressures.
Incompatibilities
Strong oxidizing agents.
Decomposition
Nitrogen oxides, carbon monoxide, carbon dioxide.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. To extinguish fire use water spray, dry chemical, carbon dioxide, or appropriate foam.

Health.
Exposure effects
Chronic ingestion may cause effects similar to those of acute ingestion. May cause reproductive and fetal effects.
   Ingestion
May cause gastrointestinal irritation with nausea, vomiting and diarrhea. May be harmful if swallowed. May cause central nervous system effects such as psychosis, hallucinations, depression, visual changes and mental changes. May cause cardiac abnormalities.
   Inhalation
Causes respiratory tract irritation.
   Skin
Causes skin irritation.
   Eyes
Causes eye irritation.

First aid
 
   Ingestion
Do NOT induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
   Inhalation
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
   Skin
Get medical aid. Immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
   Eyes
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Transport.