Lidocaine

  • Anestacon
  • alpha-Diethylaminoaceto-2,6-xylidide
  • 2-(Diethylamino)-2',6'-Acetoxylidide
  • Diethylaminoaceto-2,6-Xylidide
  • Diethylaminoacet-2,6-Xylidide
  • alpha-diethylamino-2,6-dimethylacetanilide
Formula
C14H22N2O
Structure
Description
White to yellow powder with a characteristic odor.
Uses
Medication.

Registry Numbers and Inventories.
CAS
137-58-6
EC (EINECS/ELINCS)
205-302-8
RTECS
AN7525000
RTECS class
Drug; Mutagen; Reproductive Effector; Human Data
Merck
12,5505
Beilstein/Gmelin
2215784
Beilstein Reference
4-12-00-02538
Canada DSL/NDSL
DSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed

Properties.
Formula
C14H22N2O
Formula mass
234.34
Melting point, °C
70
Boiling point, °C
351
Vapor pressure, mmHg
4E-5 (25 C)
Density
1.04 g/cm3
Solubility in water
Slightly soluble
pKa/pKb
5.47 (pKb)
Partition coefficient, pKow
2.36
Heat of fusion
15.3 kJ/mol
Heat of vaporization
59.7 kJ/mol

Hazards and Protection.
Storage
Store in a cool, dry place. Keep container closed when not in use.
Handling
Wash thoroughly after handling. Use only in a well ventilated area. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks
Sweep up or absorb material, then place into a suitable clean, dry, closed container for disposal.
Stability
Stable under normal temperatures and pressures.
Incompatibilities
Strong oxidants.
Decomposition
Nitrogen oxides, carbon monoxide, carbon dioxide.

Fire.
Flash Point,°C
166
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Extinguishing media: Use agent most appropriate to extinguish fire.

Health.
Exposure effects
Generalized depression of vital signs may follow a period of transient physiological stimulation. CNS effects invariably precede significant cardiovascular toxicity, except following massive iv injection.
   Ingestion
Harmful if swallowed. May cause gastrointestinal irritation with nausea, vomiting and diarrhea. May cause central nervous system effects. May cause headache, nausea, fatigue, and dizziness.
   Inhalation
May cause respiratory tract irritation. May cause adverse central nervous system effects including headache, convulsions, and possible death.
   Skin
May cause skin irritation.
   Eyes
May cause eye irritation.

First aid
 
   Ingestion
If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
   Inhalation
Get medical aid immediately. Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
   Skin
Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
   Eyes
Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Transport.