Lithocholic acid

  • 3alpha-hydroxycholanic acid
  • 3alpha-Hydroxy-5beta-cholanic acid
  • 3-Hydroxycholan-24-oic acid
  • 4-alpha-Hydroxy-5-beta-cholanoic acid
  • 4-alpha-Hydroxy-5-beta-cholan-24-oic acid
  • 17-beta-(1-Methyl-3-carboxypropyl)etiocholan-4-alpha-ol
Formula
C24H40O3
Structure
Description
Hexagonal leaflets (from alcohols) or prisms (from acetic acid) or white powder.
Uses
Biochemical research.

Registry Numbers and Inventories.
CAS
434-13-9
EC (EINECS/ELINCS)
207-099-1
RTECS
FZ2275000
RTECS class
Tumorigen; Mutagen; Reproductive Effector
Merck
12,5571
Beilstein/Gmelin
3217757
Beilstein Reference
4-10-00-00785

Properties.
Formula
C24H40O3
Formula mass
376.58
Melting point, °C
190
Solubility in water
Insoluble
pKa/pKb
4.76 (pKa)

Hazards and Protection.
Storage
Keep container closed when not in use. Store in a cool, dry, well-ventilated area away from incompatible substances. Keep containers tightly closed.
Handling
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks
Clean up spills immediately, using the appropriate protective equipment. Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions. Provide ventilation.
Stability
Stable under normal temperatures and pressures.
Incompatibilities
Strong oxidizing agents.
Decomposition
Carbon monoxide, carbon dioxide, acrid smoke and fumes.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. To extinguish fire, use water, dry chemical, chemical foam, or alcohol-resistant foam.
Fire potential
This material is probably combustible.

Health.
Exposure effects
   Ingestion
May cause irritation of the digestive tract.
   Inhalation
May cause respiratory tract irritation.
   Skin
May cause skin irritation.
   Eyes
May cause eye irritation.

First aid
 
   Ingestion
If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
   Inhalation
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
   Skin
Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
   Eyes
Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Transport.
4. Organic acids