Lonidamine

  • AF-1890
  • DICA
  • 1-(2,4-Dichlorbenzyl)-indazole-3-carboxylic acid
  • 1-(2,4-Dichlorobenzyl)-1H-indazole-3-carboxylic acid
  • Diclondazolic acid
  • Doridamina
Formula
C15H10Cl2N2O2
Structure
Uses
Anti-neoplastic medication.

Registry Numbers and Inventories.
CAS
50264-69-2
EC (EINECS/ELINCS)
256-510-0
60 22 40
53 22 36/37/39 45
RTECS
NK7886000
RTECS class
Drug; Mutagen; Reproductive Effector
Merck
12,5598
Beilstein/Gmelin
894483
Beilstein Reference
5-25-04-00250

Properties.
Formula
C15H10Cl2N2O2
Formula mass
321.16
Melting point, °C
207 - 208
Boiling point, °C
538
Vapor pressure, mmHg
2E-12 (25 C)
Solubility in water
Slightly soluble
pKa/pKb
3.47 (pKa)
Heat of vaporization
85.8 kJ/mol

Hazards and Protection.
Storage
Keep tightly closed. Store in a cool dry place.
Protection
Wear appropriate government approved respirator, chemical-resistant gloves, safety goggles, other protective clothing.
Small spills/leaks
Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.
Incompatibilities
Strong oxidizing agents.
Decomposition
Carbon monoxide, Carbon dioxide, Nitrogen oxides, Hydrogen chloride gas.

Fire.
Flash Point,°C
279
Fire fighting
Extinguish using Water spray. Carbon dioxide, dry chemical powder, or appropriate foam. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
Hazards
Emits toxic fumes under fire conditions.

Health.
Exposure effects
Toxic. May impair fertility. Harmful if swallowed. Limited evidence of a carcinogenic effect. Target organ(s): Ears. Testes.
   Ingestion
Harmful if swallowed.
   Inhalation
May be harmful if inhaled. Material may be irritating to mucous membranes and upper respiratory tract.
   Skin
May cause skin irritation. May be harmful if absorbed through the skin.
   Eyes
May cause eye irritation.

First aid
 
   Ingestion
If swallowed, wash out mouth with water provided person is conscious. Call a physician.
   Inhalation
If inhaled, remove to fresh air. If not breathing give artificial respiration. If breathing is difficult, give oxygen.
   Skin
In case of contact, immediately wash skin with soap and copious amounts of water.
   Eyes
In case of contact, immediately flush eyes with copious amounts of water for at least 15 minutes.

Transport.