(±)-Lorazepam

  • Delormetazepam
  • Demethyllormetazepam
  • o-Chloroxazepam
  • 7-Chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one
Formula
C15H10Cl2N2O2
Structure
Uses
Anxiolytic. US DEA Schedule IV substance.

Registry Numbers and Inventories.
CAS
846-49-1
EC (EINECS/ELINCS)
212-687-6
RTECS
DF0350000
RTECS class
Drug; Reproductive Effector; Human Data
Merck
12,5609
Beilstein/Gmelin
759084
Beilstein Reference
5-25-02-00248
Canada DSL/NDSL
DSL
Austrailia AICS
Listed
New Zealand
Listed
Korea ECL
Listed

Properties.
Formula
C15H10Cl2N2O2
Formula mass
321.16
Melting point, °C
166 - 168
Boiling point, °C
534
Vapor pressure, mmHg
3E-12 (25 C)
Solubility in water
Insoluble
pKa/pKb
10.78 (pKa)
Heat of vaporization
85.3 kJ/mol

Hazards and Protection.
Storage
Keep tightly closed.
Protection
Compatible chemical-resistant gloves. Chemical safety goggles.
Respirators
Government approved respirator.
Stability
Stable at normal temperatures and pressures.
Incompatibilities
Strong oxidizing agents.
Decomposition
Carbon monoxide, Carbon dioxide, Nitrogen oxides, Hydrogen chloride gas.

Fire.
Flash Point,°C
277
Fire fighting
Extinguish using Water spray. Carbon dioxide, dry chemical powder, or appropriate foam. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
Hazards
Emits toxic fumes under fire conditions.
Health
0
 
Flammability
0
 
 
Reactivity
0
 

Health.
Exposure effects
Harmful. Possible risk of harm to the unborn child. Calif. Prop. 65 reproductive hazard. Target organ(s): Central nervous system.
   Ingestion
Harmful if swallowed.
   Inhalation
May be harmful if inhaled. Material may be irritating to mucous membranes and upper respiratory tract.
   Skin
May cause skin irritation. May be harmful if absorbed through the skin.
   Eyes
May cause eye irritation.

First aid
 
   Ingestion
If swallowed, wash out mouth with water provided person is conscious. Call a physician immediately.
   Inhalation
If inhaled, remove to fresh air. If not breathing give artificial respiration. If breathing is difficult, give oxygen.
   Skin
In case of skin contact, flush with copious amounts of water for at least 15 minutes. Remove contaminated clothing and shoes. Call a physician.
   Eyes
In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician.

Transport.