Mandelonitrile

  • u1-Hydroxyphenylacetonitrile
Formula
C6H5CH(OH)CN
Structure
Description
Reddish-brown to dark red-brown liquid.
Uses
Preparing bitter almond water, by mixing 11 g with 500 g alc and 1489 g water.

Registry Numbers and Inventories.
CAS
532-28-5
EC (EINECS/ELINCS)
208-532-7
EC Class
toxic, irritant
R 23/24/25 36/38 50/53
S 26 36/37/39 45 60 61
RTECS
OO8400000
RTECS class
Mutagen; Natural Product; Primary Irritant
UN (DOT)
2810
Merck
13,5741
Beilstein/Gmelin
2207122
Beilstein Reference
4-10-00-00578
Swiss Giftliste 1
G-1219
Canada DSL/NDSL
NDSL
US TSCA
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed

Properties.
Formula
C8H7NO
Formula mass
133.15
Melting point, °C
-10
Boiling point, °C
170
Vapor pressure, mmHg
0.0016 (25 C)
Density
1.124 g/cm3
Solubility in water
Decomposes
Surface tension
43.91 g/s2 (20 C)
Refractive index
1.53 (20 C)
pKa/pKb
10.50 (pKa)
Partition coefficient, pKow
0.83
Heat of vaporization
55.1 kJ/mol

Hazards and Protection.
Storage
Keep containers tightly closed. Store protected from moisture. Store in a cool, dry area away from incompatible substances.
Handling
Wash thoroughly after handling. Use with adequate ventilation. Do not get in eyes, on skin, or on clothing. Keep container tightly closed. Do not ingest or inhale. Keep from contact with moist air and steam. Do not breathe vapors.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves and clothing to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.
Small spills/leaks
Wash area with soap and water. Absorb spill using an absorbent, non-combustible material such as earth, sand, or vermiculite. Provide ventilation.
Disposal code
9
Stability
Stable under normal shipping and handling conditions. However, may decompose if exposed to moist air or water.
Incompatibilities
Strong oxidizing agents, strong reducing agents, strong acids, strong bases, moisture.
Decomposition
Hydrogen cyanide, nitrogen oxides, carbon monoxide, carbon dioxide.

Fire.
Flash Point,°C
86
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. To extinguish fire, use water, dry chemical, chemical foam, or alcohol-resistant foam.
Fire potential
This chemical is combustible.
Hazards
When heated, vapors may form explosive mixtures with air: indoors, outdoors, and sewers explosion hazards.
Combustion products
Fire may produce irritating, corrosive and/or toxic gases.
Health
2
 
Flammability
1
 
 
Reactivity
0
 

Health.
Poison_Class
1
Exposure effects
Absorption into the body leads to the formation of methemoglobin which in sufficient concentrations causes cyanosis. Effects may be delayed.
   Ingestion
Metabolism may release cyanide, which may result in headache, dizziness, weakness, collapse, unconsciousness and possible death. Causes gastrointestinal tract irritation. May form methemoglobin which in sufficient concentration causes cyanosis.
   Inhalation
May cause effects similar to those described for ingestion. Causes irritation of the mucous membrane and upper respiratory tract.
   Skin
Causes skin irritation.
   Eyes
Causes severe eye irritation.

First aid
 
   Ingestion
Never give anything by mouth to an unconscious person. Get medical aid immediately. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
   Inhalation
Get medical aid immediately. Remove from exposure to fresh air immediately. Do not use mouth-to-mouth respiration if victim ingested or inhaled the substance; induce artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device.
   Skin
Get medical aid immediately. Immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
   Eyes
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Transport.
UN number
2810
Response guide
Hazard class
6.1
Packing Group
I; II; III
 
HS Code
2926 90 95