Mazindol

  • An 448
  • 5-(4-Chlorophenyl)-2,3-dihydro-5-hydroxy-5H-imidazo
  • 5-(4-Chlorophenyl)-2,5-dihydro-3H-Imidazo
  • 5-p-chlorophenyl-2,3-dihydro-5H-Imidazo(2,1-A)isoindol-5-ol
  • Dimagrir
  • Magrilon
Formula
C16H13ClN2O
Structure
Description
Crystals from acetone-hexane. Faint odor to odorless.
Uses
Medication.

Registry Numbers and Inventories.
CAS
22232-71-9
EC (EINECS/ELINCS)
244-857-0
RTECS
NI2975000
RTECS class
Drug; Mutagen; Reproductive Effector; Human Data
Merck
12,5801
Beilstein/Gmelin
546547
Beilstein Reference
5-24-04-00402
Canada DSL/NDSL
DSL
New Zealand
Listed

Properties.
Formula
C16H13ClN2O
Formula mass
284.74
Melting point, °C
215 - 217
Solubility in water
insoluble

Hazards and Protection.
Storage
Tablets should be stored in tight containers at a temperature less than 25C.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Respirators
Use NIOSH/MSHA approved respirator appropriate for exposure of concern.
Small spills/leaks
Evacuate area and ventilate. Wear protective equipment. If required, use an inert absrobent. Sweep up and place in an appropriate container for disposal. Wash contaminated surfaces.
Stability
Stable in light, air and heat.
Incompatibilities
Strong oxidizing agents.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.

Health.
Exposure effects
Severe elevated body temperature may develop. Elevated blood pressure and rapid heart rate are common. Agitation, confusion, paranoia, delirium, hallucinations, restlessness, hyperactivity, talkativeness, irritability, insomnia, and headache are common. Chorea, dystonia, fasciculations, muscle rigidity, tics, and tremors may develop. Seizures and coma may occur with severe intoxication. Other neurological effects have included stroke and cerebral vasculitis. Serotonin syndrome has occurred.
   Ingestion
Vomiting, diarrhea, cramps, anorexia and gastrointestinal hemorrhage may occur.
   Inhalation
Tachypnea is common. Pulmonary hypertension has been associated with chronic use or abuse which may result from contaminants. Pulmonary edema and ards are unusual complications of severe exposure.
   Skin
The skin is usually flushed and diaphoretic.

First aid
 
   Ingestion
Do not induce emesis. Activated charcoal: administer charcoal as a slurry (240 ml water/30 g charcoal). Usual dose: 25 to 100 g in adults/adolescents.
   Inhalation
If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.
   Skin
Remove contaminated clothing. Wash exposed area with soap and water. If symptoms persist, seek medical attention. Launder clothing before reuse.
   Eyes
If symptoms develop, immediately move individual away from exposure and into fresh air. Flush eyes gently with water for at least 15 minutes while holding eyelids apart; seek immediate medical attention.

Transport.