Melatonin

  • Melovine
  • Regulin
  • Circadin
  • N-Acetyl-5-methoxytryptamine
  • 5-Methoxy-N-acetyltryptamine
  • N-[2-(5-Methoxy-1H-indol-3-yl)ethyl]acetamide
Formula
C13H16N2O2
Structure
Description
Yellow to beige powder. Natural hormone produced by the penal grand.
Uses
Sleeping aid.

Registry Numbers and Inventories.
CAS
73-31-4
EC (EINECS/ELINCS)
200-797-7
RTECS
AC5955000
RTECS class
Tumorigen; Drug; Mutagen; Reproductive Effector; Hormone
Merck
12,5857
Beilstein/Gmelin
205542
Beilstein Reference
5-22-12-00042
Austrailia AICS
Listed
New Zealand
Listed

Properties.
Formula
C13H16N2O2
Formula mass
232.28
Melting point, °C
116 - 118
Density
1.272 g/cm3
Solubility in water
Insoluble
pKa/pKb
12.60 (pKb)
Partition coefficient, pKow
1.198

Hazards and Protection.
Storage
Store in a cool, dry place. Store in a cool, dry, well-ventilated area away from incompatible substances.
Handling
Wash thoroughly after handling. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks
Sweep up or absorb material, then place into a suitable clean, dry, closed container for disposal. Avoid generating dusty conditions.
Disposal code
3
Stability
Stable under normal temperatures and pressures.
Incompatibilities
Strong oxidizing agents.
Decomposition
Nitrogen oxides, carbon monoxide, carbon dioxide.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. To extinguish fire, use water, dry chemical, chemical foam, or alcohol-resistant foam.
Hazards
During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.

Health.
Exposure effects
   Ingestion
May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated.
   Inhalation
May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated.
   Skin
May cause skin irritation.
   Eyes
May cause eye irritation.

First aid
 
   Ingestion
If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid.
   Inhalation
Remove from exposure to fresh air immediately. Get medical aid if cough or other symptoms appear.
   Skin
Get medical aid if irritation develops or persists. Flush skin with plenty of soap and water.
   Eyes
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Transport.
HS Code
2937 90 00