Melphalan

  • 4-(bis(2-Chloroethyl)amino)-l-phenylalanine
  • 3(p-(bis(2-Chloroethyl)amino)phenyl)-l-alanine
  • Melfalan
  • L-Phenylalanine mustard
  • Phenylalanine nitrogen mustard
Formula
C13H18Cl2N2O2
Structure
Description
White to buff-colored powder. Odorless or with a faint odor.
Uses
Insect chemosterilant.

Registry Numbers and Inventories.
CAS
148-82-3
EC (EINECS/ELINCS)
205-726-3
RTECS
AY3675000
RTECS class
Tumorigen; Drug; Mutagen; Reproductive Effector; Human Data; Primary Irritant
Merck
12,5871
Beilstein/Gmelin
2816456
Beilstein Reference
4-14-00-01689
RCRA
U150
Swiss Giftliste 1
G-7460
Austrailia AICS
Listed

Properties.
Formula
C13H18Cl2N2O2
Formula mass
305.2
Melting point, °C
182 - 183
Boiling point, °C
436
Solubility in water
Insoluble
Partition coefficient, pKow
2.48

Hazards and Protection.
Storage
Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
If Tyvek-type disposable protective clothing is not worn during handling of this chemical, wear disposable Tyvek-type sleeves taped to your gloves.
Respirators
Wear a NIOSH-approved half face respirator equipped with a combination filter cartridge, i.e. organic vapor/acid gas/HEPA (specific for organic vapors, HCl, acid gas, SO2 and a high efficiency particulate filter).
Small spills/leaks
If you spill this chemical, FIRST REMOVE ALL SOURCES OF IGNITION. You should then dampen the solid spill material with 60-70% methanol, then transfer the dampened material to a suitable container. Use absorbent paper dampened with methanol to pick up any remaining material. Your contaminated clothing and absorbent paper should be sealed in a vapor-tight plastic bag for eventual disposal. Solvent-wash contaminated surfaces with 60-70% methanol followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.
Stability
No data.
Incompatibilities
Incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides.

Fire.
Fire fighting
Fires involving this material may be controlled using a dry chemical, carbon dioxide or Halon extinguisher.

Health.
Carcinogin
I-1, N-1, CP65
Poison_Class
1
Exposure effects
Seizures have occurred following parenteral melphalan overdose.
   Ingestion
See inhalation.
   Inhalation
Exposure to this compound will cause bone marrow depression. Other symptoms include neutropenia, thrombocytopenia, edema, neurotoxicity and vesiculation of the skin. It may also cause immunosuppression and, on rare occasions, pulmonary toxicity resulting in interstitial pneumonitis and lung fibrosis. It is a strong irritant to the eyes and mucous membranes. Other symptoms include nausea, vomiting, diarrhea, hemorrhage into the gastrointestinal tract, temporary alopecia and ulceration of the mouth and mucous membranes.
   Skin
Skin hypersensitivity and skin ulceration at injection site have occurred. Rare cases of scleroderma have developed after isolated limb perfusion with melphalan.
   Eyes
See inhalation

First aid
 
   Ingestion
If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. MMEDIATELY transport the victim to a hospital.
   Inhalation
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used.
   Skin
IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas.
   Eyes
First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

Transport.
USCG CHRIS Code
MPH