Menthol

  • Headache crystals
  • Hexahydrothymol
  • p-Menthan-3-ol
  • (+/-)-Menthol
  • 5-Methyl-2-(1-methylethyl)cyclohexanol
  • Peppermint camphor
Formula
C10H20O
Structure
Description
White crystalline solid with a peppermint odor and taste.
Uses
Flavoring agent in toothpastes & mouthwashes, in pharmaceuticals, principally flavoring agent in cigarettes, flavoring agent in aerosol room fresheners, in cosmetics, misc applications, topical antipruritic.

Registry Numbers and Inventories.
CAS
89-78-1
EC (EINECS/ELINCS)
201-939-0
EC Class
irritant
R 37/38 41
S 26 36/37/39
RTECS
OT0350000
RTECS class
Agricultural Chemical and Pesticide; Natural Product; Primary Irritant
Merck
12,5882
Beilstein/Gmelin
1902288
Beilstein Reference
2-06-00-00052
Swiss Giftliste 1
G-2394
Canada DSL/NDSL
DSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C10H20O
Formula mass
156.27
Melting point, °C
31 - 34
Boiling point, °C
212
Vapor pressure, mmHg
0.06 (25 C)
Density
0.904 g/cm3 (20 C)
Solubility in water
Slightly soluble
Refractive index
1.4635 (20 C)
Partition coefficient, pKow
3.3

Hazards and Protection.
Storage
Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Respirators
Wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter.
Small spills/leaks
Should a spill occur while you are handling this chemical, FIRST REMOVE ALL SOURCES OF IGNITION, then you should dampen the solid spill material with 60-70% ethanol and transfer the dampened material to a suitable container. Use absorbent paper dampened with 60-70% ethanol to pick up any remaining material. Seal the absorbent paper, and any of your clothes, which may be contaminated, in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with 60-70% ethanol followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.
Disposal code
3
Stability
No data.
Incompatibilities
Incompatible with butyl chloral hydrate, camphor, phenol, chloral hydrate, Exalgine, betanaphthol, resorcinol or thymol in triturations; potassium permanganate, chromium trioxide and pyrogallol Incompatible with strong oxidizers.

Fire.
Flash Point,°C
96
Fire fighting
Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher.
Fire potential
This chemical is combustible.

Health.
Poison_Class
4
Exposure effects
drowsiness, ataxia and coma may occur. Seizures and muscle twitching have been seen in overdosed animals.
   Ingestion
GI reflux and heartburn may occur, as may nausea, vomiting, and abdominal pain.
   Inhalation
Symptoms of exposure to this compound may include irritation of the skin, eyes, mucous membranes and upper respiratory tract. Exposure may also cause hypersensitivity reactions including contact dermatitis, spasms of the glottis and collapse in young children, urticaria, flushing, headache, insomnia, unsteady gait, thick speech, tremor of the hands, mental confusion, depression, vomiting, cramp in the legs and bradycardia. Exposure to compounds of this class may cause painless blanching or erythema, possible corrosion, profuse sweating, intense thirst, nausea, diarrhea, cyanosis from methemoglobinemia, hyperactivity, stupor, blood pressure fall, hyperpnea, abdominal pain, hemolysis, convulsions, coma and pulmonary edema followed by pneumonia. If death from respiratory failure is not immediate, jaundice and oliguria or anuria may occur. These compounds occasionally cause skin sensitization.
   Skin
Irritation, chemical burns, and skin necrosis may occur from topical use. Contact dermatitis and urticaria may be seen.
   Eyes
See inhalation

First aid
 
   Ingestion
DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician.
   Inhalation
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used.
   Skin
IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.
   Eyes
First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

Transport.
20. Alcohols. Glycols
HS Code
2906 11 00