Meprobamate

  • Amosene
  • Anathylmon
  • Tranlisant
  • Aneusral
  • Meprocompren
  • 2-Methyl-2-propyl-1,3-propanediol dicarbamate
Formula
C9H18N2O4
Structure
Description
Odorless white crystalline powder. Bitter taste.
Uses
Medication (vet).

Registry Numbers and Inventories.
CAS
57-53-4
EC (EINECS/ELINCS)
200-337-5
RTECS
TZ0175000
RTECS class
Drug; Mutagen; Reproductive Effector; Human Data
Merck
12,5908
Beilstein/Gmelin
1788882
Beilstein Reference
4-03-00-00073
Canada DSL/NDSL
DSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed

Properties.
Formula
C9H18N2O4
Formula mass
218.25
Melting point, °C
106
Density
1.182 g/cm3
Solubility in water
0.34% @ 20 C
pKa/pKb
13.09 (pKa)

Hazards and Protection.
Storage
Preparations should be stored in tight containers at a temperature less than 40C, preferably at 15 to 30C. Oral products have expiraton dates of 2-5 years, depending on dosage form and manufacturer.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Respirators
Wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter.
Small spills/leaks
Should a spill occur while you are handling this chemical, FIRST REMOVE ALL SOURCES OF IGNITION, then you should dampen the solid spill material with 60-70% ethanol and transfer the dampened material to a suitable container. Use absorbent paper dampened with 60-70% ethanol to pick up any remaining material. Seal the absorbent paper, and any of your clothes, which may be contaminated, in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with 60-70% ethanol followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.
Stability
Stable in dil acid and alkali and not broken down in gastric or intestinal juices.
Incompatibilities
Incompatible with strong acids and bases, and especially

Fire.
Fire fighting
Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher.
Fire potential
This material is probably combustible.

Health.
Exposure effects
Abnormally low blood pressure and rapid heart rate occur with severe overdose. Ataxia, slurred speech, drowsiness, lethargy and coma are common. Hypoactive deep tendon reflexes and bilateral ankle clonus may be noted. Cerebral edema may occur following severe intoxication. Coma may last for more than 48 to 72 hours.
   Inhalation
Respiratory depression and pulmonary edema may be noted.
   Eyes
Constriction of the pupil or prolonged dialation of the pupils and nystagmus may be noted.

First aid
 
   Ingestion
DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician.
   Inhalation
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used.
   Skin
IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.
   Eyes
First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. If symptoms (such as redness or irritation) develop, immediately transport the victim to a hospital.

Transport.