Metepa

  • Methyl aphoxide
  • Trimethylaziridinylphosphine oxide
  • Tris(methylaziridinyl)phosphine oxide
  • Tris(2-methyl-1-aziridinyl)phosphine oxide
  • Tris(2-methylaziridin-1-yl)phosphine oxide
  • Aziridine, 1,1',1''-phosphinylidynetris[2-methyl-
Formula
C9H18N3OP
Structure
Description
White to straw colored liquid with a strong ammonia-like odor.
Uses
Chemosterilant.

Registry Numbers and Inventories.
CAS
57-39-6
EC (EINECS/ELINCS)
200-326-5
RTECS
SZ1925000
RTECS class
Agricultural Chemical and Pesticide; Tumorigen; Drug; Mutagen; Reproductive Effector
Merck
12,5998
Beilstein/Gmelin
1345447
Swiss Giftliste 1
G-2146
Canada DSL/NDSL
DSL
US TSCA
Listed
Austrailia AICS
Listed

Properties.
Formula
C9H18N3OP
Formula mass
215.24
Boiling point, °C
90
Vapor pressure, mmHg
1 (25 C)
Density
1.079 g/cm3 (25 C)
Solubility in water
Soluble
pKa/pKb
6.78 (pKb)

Hazards and Protection.
Storage
Store in a cool, dry location - 18 C or below at all times.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Respirators
NIOSH/MSHA approved respirator with an organic vapor cartridge.
Small spills/leaks
Use water spray to disperse vapors. Use water spray to protect workers. Wear full protective equipment during cleanup. For spills, spread absorbant over spill. Shovel material into approved collection drum.
Stability
Stable at normal temperatures and pressures.
Incompatibilities
Strong oxidizing agents.
Decomposition
Nitrogen oxides and amines.

Fire.
Flash Point,°C
150
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.

Health.
Poison_Class
1*
Exposure effects
Effects may be delayed.
   Ingestion
Nausea, vomiting. See inhalation.
   Inhalation
Severely irritating, shortness of breath, decreased vital capacity, albuminara and sterility.
   Skin
Causes burns.
   Eyes
Contact may cause cornea damage.

First aid
 
   Ingestion
Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control center for advice about whether to induce vomiting. If possible, do not leave individual unattended.
   Inhalation
If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.
   Skin
Remove contaminated clothing. Wash exposed area with soap and water. If symptoms persist, seek medical attention. Launder clothing before reuse.
   Eyes
If symptoms develop, immediately move individual away from exposure and into fresh air. Flush eyes gently with water for at least 15 minutes while holding eyelids apart; seek immediate medical attention.

Transport.