Metergoline

  • Lyserdol
  • D-8b-[(Carbobenzoxyamino)methyl]-1,6-dimethyl-10a-ergoline
  • D-N-Carboxydihydro-1-methyllysergamine I benzyl ester
  • (+)-N-Carboxy-1-methyl-9,10-dihydrolysergamide benzyl ester
  • D-[(4,6,6a,7,8,9,10,10a-Octahydro-4,7-dimethyl-10aa-indolo[4,3-fg]quinolin-9b-yl)methyl]carbamic acid benzyl ester
Formula
C25H29N3O2
Structure
Uses
Used in the treatment of seasonal affective disorder.

Registry Numbers and Inventories.
CAS
17692-51-2
EC (EINECS/ELINCS)
241-686-3
20/21/22
RTECS
FA1070000
RTECS class
Drug; Reproductive Effector; Human Data
UN (DOT)
2811
Merck
12,5999
Beilstein/Gmelin
724243
Beilstein Reference
5-24
New Zealand
Listed

Properties.
Formula
C25H29N3O2
Formula mass
403.52
Melting point, °C
146 -148
Vapor pressure, mmHg
6E-15 (25 C)
Solubility in water
Insoluble
pKa/pKb
4.46 (pKb)
Heat of vaporization
90.9 kJ/mol

Hazards and Protection.
Storage
Keep tightly closed.
Protection
Compatible chemical-resistant gloves. Chemical safety goggles.
Respirators
Government approved respirator.
Small spills/leaks
Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material
Stability
Stable at normal temperatures and pressures.
Incompatibilities
Strong oxidizing agents.
Decomposition
Carbon monoxide, Carbon dioxide.

Fire.
Fire fighting
Extinguish using Water spray. Carbon dioxide, dry chemical powder, or appropriate foam. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
Fire potential
Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes.
Hazards
Emits toxic fumes under fire conditions.
Combustion products
Fire may produce irritating, corrosive and/or toxic gases.
Health
2
 
Flammability
0
 
 
Reactivity
0
 

Health.
Exposure effects
Harmful by inhalation, in contact with skin and if swallowed. Target organ(s): Pituitary.
   Ingestion
Harmful if swallowed.
   Inhalation
Harmful if inhaled. Material may be irritating to mucous membranes and upper respiratory tract.
   Skin
May cause skin irritation. Harmful if absorbed through skin.
   Eyes
May cause eye irritation.

First aid
 
   Ingestion
If swallowed, wash out mouth with water provided person is conscious. Call a physician.
   Inhalation
If inhaled, remove to fresh air. If not breathing give artificial respiration. If breathing is difficult, give oxygen.
   Skin
In case of skin contact, flush with copious amounts of water for at least 15 minutes. Remove contaminated clothing and shoes. Call a physician.
   Eyes
In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician.

Transport.
UN number
2811
Response guide
Hazard class
6.1
Packing Group
II