Methazolamide

  • Methenamide
  • Neptazane
  • Neptazaneat
  • N-(4-Methyl-2-sulfamoyl-delta2-1,3,4-thiadiazolin-5-ylidene) acetamide
  • 5-Acetylimino-4-methyl-D2-1,3,4-thiadiazoline-2-sulfonamide
Formula
C5H8N4O3S2
Structure
Uses
Diuretic.

Registry Numbers and Inventories.
CAS
554-57-4
EC (EINECS/ELINCS)
209-066-7
20/21/22 40
RTECS
AC6350000
RTECS class
Drug
Merck
13,5989
Beilstein/Gmelin
232387
Beilstein Reference
4-27-00-08221
Austrailia AICS
Listed

Properties.
Formula
C5H8N4O3S2
Formula mass
236.28
Melting point, °C
208
Boiling point, °C
402
Vapor pressure, mmHg
1E-6 (25 C)
Solubility in water
Slightly soluble
pKa/pKb
0.33 (pKa)
Heat of vaporization
65.3 kJ/mol

Hazards and Protection.
Storage
Keep tightly closed. Store in a cool dry place.
Protection
Wear appropriate government approved respirator, chemical-resistant gloves, safety goggles, other protective clothing.
Small spills/leaks
Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.
Decomposition
Carbon monoxide, Carbon dioxide, Nitrogen oxides, Sulfur oxides.

Fire.
Flash Point,°C
197
Fire fighting
Extinguish using Water spray. Carbon dioxide, dry chemical powder, or appropriate foam. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
Hazards
Emits toxic fumes under fire conditions.

Health.
Exposure effects
Properties of this material have not yet been prepared. Any recommendations are of a general nature. Many chemicals cause irritation of the eyes, skin, and respiratory tract. In severe cases respiratory tract irritation can progress to ARDS/acute lung injury which may be delayed in onset for up to 24 to 72 hours in some cases Irritation or burns of the esophagus or gastrointestinal tract are also possible if caustic or irritant chemicals are ingested. ALWAYS contact your local poision control authority or medical professional for assistance.

First aid
 
   Ingestion
If swallowed, wash out mouth with water provided person is conscious. Call a physician.
   Inhalation
If inhaled, remove to fresh air. If not breathing give artificial respiration. If breathing is difficult, give oxygen.
   Skin
In case of contact, immediately wash skin with soap and copious amounts of water.
   Eyes
In case of contact, immediately flush eyes with copious amounts of water for at least 15 minutes.

Transport.