Methoxyflurane

  • 2,2-Dichloro-1,1-difluoroethyl methyl ether
  • 2,2-Dichloro-1,1-difluoro-1-methoxyethane
  • Penthrane
  • Methoxyfluorane
  • Methoflurane
Formula
CH3OCF2CHCl2
Structure
Description
Clear colorless liquid with a sweet fruity odor.

Registry Numbers and Inventories.
CAS
76-38-0
EC (EINECS/ELINCS)
200-956-0
S 23 24/25
RTECS
KN7820000
RTECS class
Tumorigen; Drug; Mutagen; Reproductive Effector; Human Data; Primary Irritant
UN (DOT)
3271
Merck
12,6072
Beilstein/Gmelin
1737766
Beilstein Reference
4-02-00-00503
Austrailia AICS
Listed
Japan ENCS (MITI)
Listed

Properties.
Formula
C3H4Cl2F2O
Formula mass
164.97
Melting point, °C
-35
Boiling point, °C
104.6
Vapor pressure, mmHg
35 (25 C)
Density
1.4279 g/cm3 (25 C)
Solubility in water
Slightly soluble
Refractive index
1.3861 (20 C)
Partition coefficient, pKow
1.66
Heat of vaporization
33.0 kJ/mol

Hazards and Protection.
Storage
Store and handle in accordance with all current regulations and standards. Store in a tightly closed container. Avoid contact with air or light. Subject to storage regulations: U.S. OSHA 29 CFR 1910.106. Grounding and bonding required. Keep separated from incompatible substances.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Wear splash resistant safety goggles with a faceshield. Provide an emergency eye wash fountain and quick drench shower in the immediate work area. Wear appropriate chemical resistant clothing and gloves.
Respirators
Any supplied-air respirator with full facepiece and operated in a pressure-demand or other positive-pressure mode in combination with a separate escape supply. Any self-contained breathing apparatus with a full facepiece.
Small spills/leaks
If you spill this chemical, FIRST REMOVE ALL SOURCES OF IGNITION. Then, use absorbent paper to pick up all liquid spill material. Your contaminated clothing and absorbent paper should be sealed in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with 60-70% ethanol followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.
Stability
Stable at normal temperatures and pressure.
Incompatibilities
Oxidizing materials, halo carbons.
Decomposition
Halogenated compounds, oxides of carbon.

Fire.
Flash Point,°C
33
Lower exp. limit, %
7
Fire fighting
Fires involving this compound can be controlled with a dry chemical, carbon dioxide or Halon extinguisher.
Fire potential
This chemical is combustible.
Health
2
 
Flammability
3
 
 
Reactivity
0
 

Health.
Exposure limit(s)
NIOSH REL*: C 2 ppm (13.5 mg/m3) [60-minute] [*Note: REL for exposure to waste anesthetic gas.]
Exposure effects
   Ingestion
See inhalation.
   Inhalation
Symptoms: irritation eyes; central nervous system depressant/depression, analgesia, anesthesia, seizure, respiratory depressant/depression; liver, kidney injury; in animals: reproductive, teratogenic effects Target Organs: Eyes, central nervous system, liver, kidneys, reproductive system.
   Skin
See inhalation.
   Eyes
See inhalation.

First aid
 
   Ingestion
DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician.
   Inhalation
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used.
   Skin
IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.
   Eyes
First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

Transport.
UN number
3271
Response guide