Methsuximide

  • Celontin
  • 1,3-Dimethyl-3-phenyl-2,5-dioxopyrrolidine
  • 1,3-Dimethyl-3-phenyl-pyrrolidin-2,5-dione
  • N,2-Dimethyl-2-phenylsuccinimide
  • 1,3-Dimethyl-3-phenylsuccinimide
  • Mesuximide
Formula
C12H13NO2
Structure
Description
Crystals from dilute alcohol. Odorless to slight odor.
Uses
Antiepileptic drug.

Registry Numbers and Inventories.
CAS
77-41-8
EC (EINECS/ELINCS)
201-026-7
RTECS
WN2625000
RTECS class
Drug; Reproductive Effector
Merck
12,6085
Beilstein/Gmelin
168315
Beilstein Reference
5-21-11-00209
Austrailia AICS
Listed
New Zealand
Listed

Properties.
Formula
C12H13NO2
Formula mass
203.24
Melting point, °C
51
Boiling point, °C
121-122 (0.1 torr)
Solubility in water
insoluble

Hazards and Protection.
Storage
Store below 30C (86F), preferably between 15 and 30C (59 and 86F), unless otherwise specified by manufacturer. Store in a tight container. Avoid exposure to excessive heat.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Respirators
Use NIOSH/MSHA approved respirator appropriate for exposure of concern.
Small spills/leaks
Evacuate area and ventilate. Wear protective equipment. If required, use an inert absrobent. Sweep up and place in an appropriate container for disposal. Wash contaminated surfaces.
Stability
Methsuximide has a relatively low melting range (50 to 56 C or 122 to 133 F). Improper storage may result in melting and subsequent impaired absorption of the capsule contents.
Incompatibilities
Strong oxidizing agents.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.

Health.
Exposure effects
acute overdoses, alone or in combination with other anticonvulsants, produce CNS depression including coma with respiratory depression. The n-desmethyl metabolite of methsuximide (normethsuximide) may be detected for up to 60 hours after ingestion, and may produce prolonged coma. Commonly occurring dose-related effects include anorexia, drowsiness, irritability, euphoria, dizziness, headache, ataxia, hiccough, parkinsonian-like symptoms, and photophobia.
   Ingestion
Nausea and vomiting are common dose-related effects. Coffee ground vomiting has been reported following methsuximide overdose.
   Skin
Skin rashes have been reported.

First aid
 
   Ingestion
Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control center for advice about whether to induce vomiting. If possible, do not leave individual unattended.
   Inhalation
If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.
   Skin
Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
   Eyes
If symptoms develop, immediately move individual away from exposure and into fresh air. Flush eyes gently with water for at least 15 minutes while holding eyelids apart; seek immediate medical attention.

Transport.