Methyl acetoacetate

  • Methyl acetylacetate
  • Methyl 3-oxobutanoate
  • 3-Oxobutanoic acid methyl
Formula
CH3COCH2COOCH3
Structure
Description
Colorless liquid.
Uses
Solvent for cellulose ethers, component of solvent mixtures for cellulose esters, chemical intermediate for organic compounds.

Registry Numbers and Inventories.
CAS
105-45-3
EC (EINECS/ELINCS)
203-299-8
EC Index Number
607-137-00-0
EC Class
Irritant
RTECS
AK5775000
RTECS class
Primary Irritant
Merck
12,6090
Beilstein/Gmelin
506727
Beilstein Reference
4-03-00-01527
Swiss Giftliste 1
G-4315
Canada DSL/NDSL
DSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C5H8O3
Formula mass
116.12
Melting point, °C
-39
Boiling point, °C
170
Vapor pressure, mmHg
0.7 (20 C)
Vapor density (air=1)
4.0
Saturation Concentration
900 ppm; 1700 ppm at 20 C (calculated)
Odor Threshold Odor threshold .
Density
1.076 g/cm3 (20 C)
Solubility in water
Soluble
Viscosity
1.566 cp (25 C)
Refractive index
1.418 (20 C)
pKa/pKb
10.67 (pKa)
Partition coefficient, pKow
-0.264
Heat of combustion
-2486 kJ/mol

Hazards and Protection.
Storage
Store in a cool, dry place. Keep container closed when not in use.
B3 D2B
Handling
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation.
Protection
Wear appropriate chemical protective gloves, boots and goggles.
Respirators
Wear a NIOSH/MSHA or European Standard EN 149 approved full-facepiece airline respirator in the positive pressure mode with emergency escape provisions.
Small spills/leaks
Absorb spill with inert material, (e.g., dry sand or earth), then place into a chemical waste container. Clean up spills immediately, using the appropriate protective equipment.
Disposal code
1
Stability
Stable under normal temperatures and pressures.
Incompatibilities
Oxidizing agents - bases.
Decomposition
Carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.

Fire.
Flash Point,°C
67
Autoignition, °C
350
Upper exp. limit, %
11
Lower exp. limit, %
1.3
Fire fighting
Do not extinguish fire unless flow can be stopped. Use water in flooding quantities as fog. Solid streams of water may be ineffective. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Use alcohol foam, dry chemical or carbon dioxide.
Fire potential
Moderate fire hazard, when exposed to heat, flame or oxidizers.
Health
2
 
Flammability
2
 
 
Reactivity
0
 

Health.
Poison_Class
4
Exposure effects
   Ingestion
Nausea, vomiting and diarrhea are possible if ingested.
   Inhalation
Cough, tachypnea, and wheezing are common after inhalation.
   Skin
Redness, swelling and pain may occur.
   Eyes
Irritants may cause swelling, redness and pain at any site, especially at mucous membranes. The mouth, nose, and eyes are susceptible to these effects.

First aid
 
   Ingestion
Do NOT induce vomiting. Allow the victim to rinse his mouth and then to drink 2-4 cupfuls of water, and seek medical advice.
   Inhalation
Remove from exposure to fresh air immediately.
   Skin
Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
   Eyes
Flush eyes with copious amounts of water for at least 15 minutes.

Transport.
USCG CHRIS Code
MAE
 
HS Code
2918 30 00
 
Std. Transport #
4913150
 
IMO Pollution Category
D