Methyl bromoacetate

  • Bromoacetic acid methyl ester
Formula
BrCH2COOCH3
Structure
Description
A colorless to straw-colored liquid with a sharp penetrating odor.
Uses
Used to make vitamins and pharmaceuticals.

Registry Numbers and Inventories.
CAS
96-32-2
EC (EINECS/ELINCS)
202-499-2
EC Class
toxic, irritant
R 23/24/25 34
S 26 36/37/39 45
RTECS
AF6300000
RTECS class
Other
UN (DOT)
2643
Beilstein/Gmelin
506256
Beilstein Reference
4-02-00-00527
Swiss Giftliste 1
G-5465
Canada DSL/NDSL
DSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed

Properties.
Formula
C3H5BrO2
Formula mass
152.98
Melting point, °C
-50
Boiling point, °C
145
Vapor pressure, mmHg
3.3 (25 C)
Vapor density (air=1)
5.28
Critical temperature
334
Critical pressure
48.1
Density
1.6350 g/cm3 (20 C)
Solubility in water
Slightly soluble
Refractive index
1.4520 (20 C)
Partition coefficient, pKow
0.87
Heat of vaporization
39.1 kJ/mol

Hazards and Protection.
Storage
Keep away from heat, sparks, and flame. Keep away from sources of ignition. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
Handling
Wash thoroughly after handling. Use only in a well ventilated area. Avoid contact with eyes, skin, and clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Avoid contact with heat, sparks and flame. Avoid ingestion and inhalation. Use only in a chemical fume hood. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames. Do not breathe vapors.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.
Small spills/leaks
Clean up spills immediately, using the appropriate protective equipment. Cover with sand, dry lime or soda ash and place in a closed container for disposal. Remove all sources of ignition. Use a spark-proof tool. Provide ventilation.
Disposal code
2
Stability
Stable at room temperature in closed containers under normal storage and handling conditions.
Incompatibilities
Acids, bases, oxidizing agents, reducing agents.
Decomposition
Carbon monoxide, carbon dioxide, hydrogen bromide.

Fire.
Flash Point,°C
60
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use water spray to keep fire-exposed containers cool. Combustible Liquid. Extinguishing media: Use water spray to cool fire-exposed containers. In case of fire, use carbon dioxide, dry chemical powder or appropriate foam.
Fire potential
HIGHLY FLAMMABLE.
Hazards
Vapors form explosive mixtures with air: indoors, outdoors, and sewers explosion hazards. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapors may travel to source of ignition and flash back. Substance will react with water (some violently) releasing flammable, toxic or corrosive gases and runoff. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated or if contaminated with water.
Combustion products
Fire will produce irritating, corrosive and/or toxic gases.
Health
2
 
Flammability
2
 
 
Reactivity
0
 

Health.
Poison_Class
1
Exposure effects
Effects may be delayed.
   Ingestion
Harmful if swallowed. May cause gastrointestinal irritation with nausea, vomiting and diarrhea. The toxicological properties of this substance have not been fully investigated.
   Inhalation
May cause severe irritation of the respiratory tract with sore throat, coughing, shortness of breath and delayed lung edema. Inhalation at high concentrations may cause CNS depression and asphixiation. Harmful if inhaled.
   Skin
May cause severe skin irritation. Harmful if absorbed through the skin. May cause dermatitis. May cause cyanosis of the extremities.
   Eyes
May cause severe eye irritation. Lachrymator. May cause chemical conjunctivitis and corneal damage.

First aid
 
   Ingestion
Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
   Inhalation
Get medical aid immediately. Remove from exposure to fresh air immediately. If breathing is difficult, give oxygen. Do not use mouth-to-mouth respiration if victim ingested or inhaled the substance; induce artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device.
   Skin
Get medical aid immediately. Immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
   Eyes
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid. Do NOT allow victim to rub or keep eyes closed.

Transport.
UN number
2643
Response guide
Hazard class
6.1
Packing Group
II
 
HS Code
2915 90 80
 
Std. Transport #
4921592