Methyl isobutyl ketone

  • 4-Methyl-2-pentanone
  • Isobutyl methyl ketone
  • Hexone
  • 4-Methylpentan-2-one
Formula
(CH3)2CHCH2COCH3
Structure
Description
Clear, colorless liquid with a sweet, camphor-like odor.
Uses
Solvent for vinyl, epoxy, acrylic and natural resins. Solvent for nitrocellulose and dyes.

Registry Numbers and Inventories.
CAS
108-10-1
EC (EINECS/ELINCS)
203-550-1
EC Index Number
606-004-00-4
EC Class
Highly flammable; Harmful; Irritant; Repeated exposure may cause skin dryness or cracking
R 11 20 36/37 66
S 9 16 29
RTECS
SA9275000
RTECS class
Tumorigen; Reproductive Effector; Human Data; Primary Irritant
UN (DOT)
1245
Merck
13,5227
Beilstein/Gmelin
605399
Beilstein Reference
4-01-00-03305
RCRA
U161
EPA OPP
44105
Swiss Giftliste 1
G-2468
Canada DSL/NDSL
DSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C6H12O
Formula mass
100.16
Melting point, °C
-84
Boiling point, °C
117.4
Vapor pressure, mmHg
20 (25 C)
Vapor density (air=1)
3.45
Saturation Concentration
0.79% @ 20 C
Evaporization number
1.6 (butyl acetate=1)
Odor Threshold Odor threshold 0.10 ppm
Critical temperature
301
Critical pressure
32.27
Density
0.801 g/cm3
Solubility in water
20 g/L
Viscosity
0.00542 g/(cm s)
Surface tension
23.6 g/s2
Refractive index
1.396 (20 C)
Dipole moment
13.11 D (20 C)
Dielectric constant
13.1 (20 C)
Partition coefficient, pKow
1.31
Heat of vaporization
40.56 kJ/mol
Heat of combustion
-3697 kJ/mol

Hazards and Protection.
Storage
Keep away from sources of ignition. Store in a cool, dry, well-ventilated area away from incompatible substances. Flammables-area.
B2
Handling
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Ground and bond containers when transferring material. Use spark-proof tools and explosion proof equipment. Avoid contact with skin and eyes. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Avoid ingestion and inhalation. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to minimize contact with skin.
Respirators
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks
Avoid runoff into storm sewers and ditches which lead to waterways. Wear a self contained breathing apparatus and appropriate Personal protection. (See Exposure Controls, Personal Protection section). Scoop up with a nonsparking tool, then place into a suitable container for disposal. Remove all sources of ignition. Absorb spill using an absorbent, non-combustible material such as earth, sand, or vermiculite. Provide ventilation.
Disposal code
1
Stability
Stable at room temperature in closed containers under normal storage and handling conditions. Can form and accumulate peroxides which may explode when subjected to heat or shock. This material is most hazardous when peroxide levels are concentrated by distillation or evaporation.
Incompatibilities
Aldehydes, nitric acid, perchloric acid, strong oxidizers, strong reducing agents. Violent reaction with potassium tert-butoxide.
Decomposition
Carbon monoxide, carbon dioxide.

Fire.
Flash Point,°C
14
Autoignition, °C
448
Upper exp. limit, %
8.0
Lower exp. limit, %
1.2
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing media: For small fires, use dry chemical, carbon dioxide, water spray or alcohol-resistant foam. Water may be ineffective. For large fires, use water spray, fog or alcohol-resistant foam. Do NOT use straight streams of water. Cool containers with flooding quantities of water until well after fire is out.
Fire potential
Flammable liquid and vapor.
Hazards
Vapor is heavier than air (vapor-air density at 100 deg f, 1:1) and may travel considerable distance to source of ignition and flash back. Containers may explode in the heat of a fire. May polymerize explosively when involved in a fire.
Combustion products
Irritating vapors are generated when heated.
Health
2
 
Flammability
3
 
 
Reactivity
0
 

Health.
Exposure limit(s)
OSHA PEL: TWA 100 ppm (410 mg/m3) NIOSH REL: TWA 50 ppm (205 mg/m3) ST 75 ppm (300 mg/m3) NIOSH IDLH: 500 ppm
Poison_Class
4
Exposure effects
Prolonged skin contact may defat the skin and produce dermatitis. Based on animal studies, chronic exposure may affect liver and kidneys.
   Ingestion
May produce abdominal pain, nausea. Aspiration into lungs can produce severe lung damage and is a medical emergency. Other symptoms expected to parallel inhalation.
   Inhalation
Causes irritation to the nose and throat. Concentrations above the TLV may cause headache, dizziness, nausea, shortness of breath, and vomiting. Higher concentrations may cause central nervous system depression and unconsciousness.
   Skin
Causes irritation to skin. Symptoms include redness, itching, and pain.
   Eyes
Vapors may cause eye irritation. May cause painful sensitization to light. Splashes produces irritation, tearing, and burning pain.

First aid
 
   Ingestion
If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
   Inhalation
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid if cough or other symptoms appear.
   Skin
Immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Get medical aid if irritation develops or persists. Wash clothing before reuse.
   Eyes
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately. Do NOT allow victim to rub or keep eyes closed.

Transport.
UN number
1245
Response guide
Hazard class
3
Packing Group
II
 
USCG CHRIS Code
MIK
 
HS Code
2914 13 00
 
Std. Transport #
4909244
 
IMO Chemical Code
18
IMO Pollution Category
D