- Isocyanic acid, methyl ester
- Methyl ester of isocyanic acid
Registry Numbers and Inventories.
EC Index Number
Extremely flammable; Toxic; Irritant
Mutagen; Reproductive Effector; Human Data; Primary Irritant
Swiss Giftliste 1
Melting point, °C
Boiling point, °C
Vapor pressure, mmHg
531 (25 C)
Vapor density (air=1)
0.9744 g/cm3 (15 C)
Solubility in water
1.3718 (14.9 C)
Partition coefficient, pKow
Heat of vaporization
Heat of combustion
Hazards and Protection.
Keep cool, no sparks, flames. Store in areas separated from oxidizers. store in stainless steel receptacles, nickel, or perfectly vitrified materials.
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Wear appropriate protective gloves, clothing and goggles.
Wear positive pressure self-contained breathing apparatus (SCBA).
Keep sparks, flames, and other sources of ignition away. Keep material out of water sources and sewers. Build dikes to contain flow as necessary. Attempt to stop leak if without undue personnel hazard. Use water spray to knock-down vapors.
Exploded violently when dropped on hot surface. Dried out material may explode if exposed to heat, flame, or shock. Runoff to sewer may create fire or explosion hazard.
Reacts rapidly with acids and bases (including amines) Attacks some plastics, rubbers, and coatings.
Upper exp. limit, %
Lower exp. limit, %
Material is extremely hazardous to health but areas may be entered with extreme care. Full protective clothing, including self-contained breathing apparatus (coat, pants, gloves, boots, and bands around legs, arms and waist) should be provided. No skin surface should be exposed. Stay away from ends of tanks. Do not get water inside container. Spray cooling water on containers that are exposed to flames until well after fire is out. Withdraw immediately in case of rising sound from venting safety device or any discoloration of tank due to fire.Small fires: dry chemical, carbon dioxide, water spray, or foam. Large fires: water spray, fog, or foam.
May be ignited by heat, sparks, or flames. Vapors may travel to a source of ignition and flash back. Container may explode violently in heat of fire. Vapor explosion and poison hazard indoors, outdoors, or in sewers.
Methyl isocyanate vapors and hydrogen cyanide will be emitted in a fire.
NIOSH REL: TWA 0.02 ppm (0.05 mg/m3)[skin] OSHA PEL: TWA 0.02 ppm (0.05 mg/m3) [skin] IDLH 3 ppm
Acute exposure may cause dyspnea. Pulmonary edema-induced hypoxia may produce CNS depression. There is conflicting data as to whether methyl isocyanate is fetotoxic, however, it crosses the placental barrier. Reports from Bhopal, India and animal studies suggest a high degree of adverse reproductive effects and teratogenicity.
Gastrointestinal irritation and vomiting may occur.
TOXIC; inhalation, ingestion or contact (skin, eyes) with vapors, dusts or substance may cause severe injury, burns, or death. Effects may be delayed.
Skin irritation is likely. Contact can cause chemical burns (sittig, 1991; hsdb, 2001).
Contact with the eye is extremely irritating and may cause permanent damage with cataract formation, trachoma and chronic blepharitis.
Administer charcoal as a slurry (240 ml water/30 g charcoal). Usual dose: 25 to 100 g in adults/adolescents.
Move victim to fresh air. Apply artificial respiration if victim is not breathing. Do not use mouth-to-mouth method if victim ingested or inhaled the substance; induce artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device. Administer oxygen if breathing is difficult.
Remove and isolate contaminated clothing and shoes. Immediately flush with running water for at least 20 minutes. For minor skin contact, avoid spreading material on unaffected skin.
Immediately flush with running water for at least 20 minutes.