Methyl magnesium chloride
Alkylating agent in organic synthesis, grignard reagent.
Registry Numbers and Inventories.
Japan ENCS (MITI)
Boiling point, °C
Hazards and Protection.
Keep away from sources of ignition. Store in a cool, dry place. Store in a tightly closed container. Keep away from water. Water free area.
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Wear appropriate protective gloves, clothing and goggles.
Wear positive pressure self-contained breathing apparatus (SCBA).
ELIMINATE all ignition sources and prevent contact. Stop leak if you can do it without risk. Use water spray to reduce vapors or divert vapor cloud drift. Avoid allowing water runoff to contact spilled material. However DO NOT GET WATER on spilled substance or inside containers. Cover with DRY earth, DRY sand, or other non-combustible material followed with plastic sheet to minimize spreading or contact with rain. For powers, cover with plastic sheet or tarp to minimize spreading and keep powder dry. DO NOT CLEAN-UP OR DISPOSE OF, EXCEPT UNDER SUPERVISION OF A SPECIALIST.
Oxidizing agents, acids, alcohols.
Hydrogen chloride, carbon monoxide, carbon dioxide.
Upper exp. limit, %
Lower exp. limit, %
DO NOT USE WATER OR FOAM. Small Fire: Dry chemical, soda ash, lime or sand. Large Fires: DRY sand, dry chemical, soda ash or lime or withdraw from area and let fire burn.
Dangerous fire risk.
May ignite on contact with water or moist air. Some react vigorously or explosively on contact with water. May be ignited by heat, sparks or flames. May re-ignite after fire is extinguished. May be transported in highly flammable liquids.
Fire will produce irritating, corrosive and/or toxic gases.
Lethargy, hyporeflexia, weakness, and subjective feeling of thirst and heat may occur. Excessive absorption of magnesium from cathartics may result in CNS depression and seizures, most notably in renal failure patients.
Inhalation or contact with vapors, substance, or decomposition products may cause severe injury or death.
Cutaneous flushing may be noted.
Activated charcoal does not effectively adsorb magnesium salts. Monitor ecg and vital signs frequently. Cardiovascular and/or respiratory assistance may be required. Calcium - to temporarily ameliorate respiratory depression, administer iv calcium chloride 10% (dose: 0.2 To 0.5 Ml/kg/dose up to 10 ml/dose over 5 to 10 minutes). Monitor ecg during infusion and stop if heart rate begins to decrease. Repeat dose if needed. Hypotension: infuse 10 to 20 ml/kg isotonic fluid, place in trendelenburg position. If hypotension persists, administer dopamine (5 to 20 mcg/kg/min) or norepinephrine (0.1 To 0.2 Mcg/kg/min), titrate to desired response. Hypothermia - place patient under a warming blanket or a hugg-bear or equivalent device. Hemodialysis - is the most effective method to remove significant quantities of magnesium and may reverse life-threatening symptoms within 30 minutes.
Move patient to fresh air. Monitor for respiratory distress. If cough or difficulty breathing develops, evaluate for respiratory tract irritation, bronchitis, or pneumonitis. Administer oxygen and assist ventilation as required. Treat bronchospasm with beta2 agonist and corticosteroid aerosols.
Remove contaminated clothing, wash exposed area with copious amounts of water. A physician should examine the area if irritation or pain persists.
Irrigate exposed eyes with copious amounts of tepid water for at least 15 minutes. If irritation, pain, swelling, lacrimation, or photophobia persist, the patient should be seen in a health care facility. Medical facility: irrigate with sterile 0.9% Saline for at least an hour.
I; II; III