- Methylphosphonyl dichloride
- Dichloromethyl phosphine oxide
For the preparation of oligonucleotides containing methylphosphonates at defined sites.
Registry Numbers and Inventories.
R 14 26 34
S 26 28 36/37/39 45
Melting point, °C
Boiling point, °C
Vapor pressure, mmHg
1.4559 g/cm3 (25 C)
Solubility in water
1.4562 (25 C)
Partition coefficient, pKow
Heat of vaporization
Hazards and Protection.
Keep tightly closed, stored under nitrogen, away from moisture.
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Wear appropriate protective gloves, clothing and goggles.
Wear positive pressure self-contained breathing apparatus (SCBA).
Keep sparks, flames, and other sources of ignition away. Keep material out of water sources and sewers. Build dikes to contain flow as necessary. Attempt to stop leak if without undue personnel hazard. Use water spray to knock-down vapors.
Stable undr normal temperatures and pressures.
Incompatible with water, strong oxidizing agents, alcohols, bases (including amines) May react vigorously or explosively
Oxides of carbons, toxic funes of phosphorus oxides and phosphine.
Keep unnecessary people away; isolate hazard area and deny entry. Stay upwind; keep out of low areas. Ventilate closed spaces before entering them. Wear positive pressure breathing apparatus and special protective clothing.Do not get water inside container. Small fires: dry chemical or carbon dioxide. Large fires: flood fire area with water from a distance. Do not get solid stream of water on spilled material. Move container from fire area if you can do so without risk. Spray cooling water on containers that are exposed to flames until well after fire is out.
This material may burn but does not ignite readily.
May ignite other combustible materials (wood, paper, oil, etc.). Reacts violently with water. Flammable poisonous gases may accumulate in tanks and hopper cars. Runoff to sewer may create fire or explosion hazard. Contact causes severe burns to skin and eyes. Runoff from fire control or dilution water may cause pollution. Violent reaction with water.
Fire will produce irritating, corrosive and/or toxic gases. Reaction with water may generate much heat which will increase the concentration of fumes in the air.
The toxological properties of this substance have not been fully investigated.
May cause severe injury, burns, or death.
Seek medical assistance.
Move victim to fresh air. Apply artificial respiration if victim is not breathing. Do not use mouth-to-mouth method if victim ingested or inhaled the substance; induce artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device.Administer oxygen if breathing is difficult.
Remove and isolate contaminated clothing and shoes. In case of contact with substance, immediately flush with running water for at least 20 minutes. For minor skin contact, avoid spreading material on unaffected skin.
In case of contact with substance, immediately flush with running water for at least 20 minutes.
USCG CHRIS Code
Std. Transport #