Methylphosphonic dichloride

  • Methylphosphonyl dichloride
  • Dichloromethyl phosphine oxide
Formula
CH3Cl2OP
Structure
Description
Colorless liquid.
Uses
For the preparation of oligonucleotides containing methylphosphonates at defined sites.

Registry Numbers and Inventories.
CAS
676-97-1
EC (EINECS/ELINCS)
211-634-4
R 14 26 34
S 26 28 36/37/39 45
RTECS
TA1840000
RTECS class
Other
UN (DOT)
9206
Beilstein/Gmelin
1071305
Beilstein Reference
4-04-00-03509
Canada DSL/NDSL
NDSL
US TSCA
Listed
Austrailia AICS
Listed

Properties.
Formula
CH3Cl2OP
Formula mass
132.91
Melting point, °C
32
Boiling point, °C
163
Vapor pressure, mmHg
2.8 kJ/mol
Density
1.4559 g/cm3 (25 C)
Solubility in water
15 g/L
Refractive index
1.4562 (25 C)
Partition coefficient, pKow
0.26
Heat of vaporization
38.3 kJ/mol

Hazards and Protection.
Storage
Keep tightly closed, stored under nitrogen, away from moisture.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Wear appropriate protective gloves, clothing and goggles.
Respirators
Wear positive pressure self-contained breathing apparatus (SCBA).
Small spills/leaks
Keep sparks, flames, and other sources of ignition away. Keep material out of water sources and sewers. Build dikes to contain flow as necessary. Attempt to stop leak if without undue personnel hazard. Use water spray to knock-down vapors.
Stability
Stable undr normal temperatures and pressures.
Incompatibilities
Incompatible with water, strong oxidizing agents, alcohols, bases (including amines) May react vigorously or explosively
Decomposition
Oxides of carbons, toxic funes of phosphorus oxides and phosphine.

Fire.
Flash Point,°C
44
Fire fighting
Keep unnecessary people away; isolate hazard area and deny entry. Stay upwind; keep out of low areas. Ventilate closed spaces before entering them. Wear positive pressure breathing apparatus and special protective clothing.Do not get water inside container. Small fires: dry chemical or carbon dioxide. Large fires: flood fire area with water from a distance. Do not get solid stream of water on spilled material. Move container from fire area if you can do so without risk. Spray cooling water on containers that are exposed to flames until well after fire is out.
Fire potential
This material may burn but does not ignite readily.
Hazards
May ignite other combustible materials (wood, paper, oil, etc.). Reacts violently with water. Flammable poisonous gases may accumulate in tanks and hopper cars. Runoff to sewer may create fire or explosion hazard. Contact causes severe burns to skin and eyes. Runoff from fire control or dilution water may cause pollution. Violent reaction with water.
Combustion products
Fire will produce irritating, corrosive and/or toxic gases. Reaction with water may generate much heat which will increase the concentration of fumes in the air.

Health.
Exposure effects
The toxological properties of this substance have not been fully investigated.
   Ingestion
See inhalation.
   Inhalation
May cause severe injury, burns, or death.
   Skin
See Inhalation.
   Eyes
See Inhalation.

First aid
 
   Ingestion
Seek medical assistance.
   Inhalation
Move victim to fresh air. Apply artificial respiration if victim is not breathing. Do not use mouth-to-mouth method if victim ingested or inhaled the substance; induce artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device.Administer oxygen if breathing is difficult.
   Skin
Remove and isolate contaminated clothing and shoes. In case of contact with substance, immediately flush with running water for at least 20 minutes. For minor skin contact, avoid spreading material on unaffected skin.
   Eyes
In case of contact with substance, immediately flush with running water for at least 20 minutes.

Transport.
UN number
9206
Response guide
Hazard class
6.1
PRTC
T
Packing Group
I
 
USCG CHRIS Code
MDD
 
Std. Transport #
4921695