Methylprednisolone

  • Artisone-wyeth
  • Besonia
  • 1-Dehydro-6-alpha-Methylhydrocortisone
  • Dopomedrol
  • Medesone
  • Medrate
Formula
C22H30O5
Structure
Description
Crystals. Odorless.
Uses
Medication.

Registry Numbers and Inventories.
CAS
83-43-2
EC (EINECS/ELINCS)
201-476-4
RTECS
TU4146000
RTECS class
Drug; Human Data
UN (DOT)
1325
Merck
12,6189
Beilstein/Gmelin
2340300
Beilstein Reference
4-08-00-03498
Canada DSL/NDSL
NDSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed

Properties.
Formula
C22H30O5
Formula mass
374.48
Melting point, °C
230
Solubility in water
practically insoluble

Hazards and Protection.
Storage
Store in a cool, dry place. Store in a tightly closed container.
Handling
Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes.
Protection
Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks
Vacuum or sweep up material and place into a suitable disposal container.
Stability
Stable under normal shipping and handling conditions.
Incompatibilities
Strong oxidizing agents, acids, acid chlorides, carbon dioxide, acid anhydrides.
Decomposition
Nitrogen oxides, carbon monoxide, carbon dioxide.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Extinguishing media: Use foam, dry chemical, or carbon dioxide.
Fire potential
Flammable/combustible material. May be ignited by friction, heat, sparks or flames.
Combustion products
Fire may produce irritating and/or toxic gases.

Health.
Exposure effects
seizures have been reported following pulse methylprednisolone therapy.
   Ingestion
Harmful if swallowed.
   Inhalation
Harmful if inhaled. May cause irritation of the respiratory tract with burning pain in the nose and throat, coughing, wheezing, shortness of breath and pulmonary edema.
   Skin
Harmful if absorbed through the skin.
   Eyes
May cause eye irritation.

First aid
 
   Ingestion
Get medical aid. Wash mouth out with water.
   Inhalation
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
   Skin
Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
   Eyes
Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Transport.
UN number
1325
Response guide
Hazard class
4.1
Packing Group
II; III