Methylscopolamine nitrate

  • Epoxytropine tropate methylnitrate
  • Mescomine
  • Methscopolamine nitrate
  • Scopolamine methylnitrate
  • Skopolate
  • (-)-N-Methylhyoscinium nitrate
Formula
C17H21NO4.CH3NO3
Structure
Description
White crystalline powder. Odorless.
Uses
Medication.

Registry Numbers and Inventories.
CAS
6106-46-3
EC (EINECS/ELINCS)
228-065-2
RTECS
YM3675150
RTECS class
Other
UN (DOT)
1477
Beilstein/Gmelin
7243890
Canada DSL/NDSL
NDSL
US TSCA
Listed
Japan ENCS (MITI)
Listed

Properties.
Formula
C18H24NO4*NO3
Formula mass
380.39
Solubility in water
freely soluble

Hazards and Protection.
Storage
Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Wear appropriate protective gloves, clothing and goggles.
Respirators
Wear positive pressure self-contained breathing apparatus (SCBA).
Small spills/leaks
Keep away from combustible materials. Avoid contact unless wearing appropriate protective clothing. Stop leak if you can do it without risk. With clean shovel place material into clean, dry container and cover loosely; move containers from spill area.
Stability
No data.

Fire.
Fire fighting
Small Fires: Use water. Do not use dry chemicals or foams. carbon dioxide or Halon may provide limited control. Large Fires: Flood fire area with water from a distance.
Fire potential
These substances will accelerate burning when involved in a fire.
Hazards
May explode from heat or contamination. May react explosively with hydrocarbons (fuels). May ignite combustibles.
Combustion products
Fire may produce irritating, corrosive and/or toxic gases.
 
Special
O

Health.
Exposure effects
Vital sign changes include rapid heart rate and elevated blood pressure. Both elevated body temperature and reduced body temperature have been reported, but elevated body temperature is more common. toxic psychosis (disorientation, delirium, hallucinations, and paranoia associated with anxiety, agitation, and hyperactivity) has been reported. Memory loss has also been noted as a toxic anticholinergic effect. Seizures, dystonic reactions, and dyskinesias may occur at recommended doses. Severe poisoning may produce coma, medullary paralysis, and death.
   Ingestion
Decreased gastric motility, diminished bowel sounds, esophageal atony and dilatation, colonic distention, and paralytic ileus may occur as a result of anticholinergic toxicity.
   Inhalation
Respiratory depression, respiratory failure, and aspiration may occur in severe overdoses.
   Skin
Warm red skin with decreased sweating is common. Delayed hypersensitivity has also been reported.
   Eyes
Warm red skin, decreased sweating, dry oral mucous membranes, and widely dilated pupils are common.

First aid
 
   Ingestion
Gastric emptying may be successful even if delayed. Anticholinergics slow gi motility; sustained-release preparations are available. Emesis: ipecac-induced vomiting is not recommended because of the potential for cns depression and seizures. Consider after ingestion of a potentially life-threatening amount of poison if it can be performed soon after ingestion (generally within 1 hour).
   Inhalation
Move victim to fresh air. Apply artificial respiration if victim is not breathing. Administer oxygen if breathing is difficult.
   Skin
Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
   Eyes
In case of contact with substance, immediately flush with running water for at least 20 minutes.

Transport.
UN number
1477
Response guide
Hazard class
5.1
Packing Group
II; III