Metirosine

  • L-a-Methyltyrosine
  • Metyrosine
  • a-Methyl-L-tyrosine
  • Demser
Formula
C10H13NO3
Structure
Description
White powder.

Registry Numbers and Inventories.
CAS
672-87-7
EC (EINECS/ELINCS)
211-599-5
S: 22 24/25
Merck
12,6248

Properties.
Formula
C10H13NO3
Formula mass
195.22
Melting point, °C
189 - 191
Vapor pressure, mmHg
1.4E-6 (25 C)
Density
1.283 g/cm3 (20 C)
Solubility in water
Slightly soluble
pKa/pKb
2.29 (pKa)
Partition coefficient, pKow
0.73

Hazards and Protection.
Storage
Keep tightly closed. Store in the dark. Store at -20 C.
Protection
Impervious gloves, chemical safety goggles.
Respirators
Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU). Respiratory protection is not required. Where protection from nuisance levels of dusts are desired, use type N95 (US) or type P1 (EN 143) dust masks.
Small spills/leaks
Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.
Stability
Stable at normal temperatures and pressures.
Incompatibilities
Strong oxidizing agents.
Decomposition
Oxides of carbon and nitrogen.

Fire.
Fire fighting
Extinguish using water spray, carbon dioxide, dry chemical powder, or appropriate foam. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
Combustion products
Emits toxic fumes under fire conditions.
Health
1
 
Flammability
0
 
 
Reactivity
1
 

Health.
Exposure effects
   Ingestion
May be harmful if swallowed.
   Inhalation
Material may be irritating to mucous membranes and upper respiratory tract. May be harmful if inhaled.
   Skin
May cause skin irritation. May be harmful if absorbed through the skin.
   Eyes
May cause eye irritation.

First aid
 
   Ingestion
If swallowed, wash out mouth with water provided person is conscious. Call a physician.
   Inhalation
If inhaled, remove to fresh air. If breathing becomes difficult, call a physician.
   Skin
In case of contact, immediately wash skin with soap and copious amounts of water.
   Eyes
In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician.

Transport.