Milrinone

  • 1,6-Dihydro-2-methyl-6-oxo-(3,4'-bipyridine)-5-carbonitrile
  • WIN-47203
  • YM-018
Formula
C12H9N3O
Structure
Description
white solid
Uses
Potent cardiotonic, positive inotropic vasodilator.

Registry Numbers and Inventories.
CAS
78415-72-2
EC (EINECS/ELINCS)
278-903-6
RTECS
DW1762000
RTECS class
Drug
UN (DOT)
2811
Merck
12,6284
Beilstein/Gmelin
3546821
Beilstein Reference
6-25

Properties.
Formula
C12H9N3O
Formula mass
211.22
Melting point, °C
313 - 316
Boiling point, °C
449
Vapor pressure, mmHg
3E-8 (25 C)
Density
1.344 g/cm3
Solubility in water
Insoluble
pKa/pKb
8.83 (pKa)
Partition coefficient, pKow
0.00
Heat of vaporization
70.7 kJ/mol

Hazards and Protection.
Storage
Keep tightly closed. Store at 2-8 C
Protection
Compatible chemical-resistant gloves. Chemical safety goggles.
Respirators
Government approved respirator.
Small spills/leaks
Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.
Stability
Stable at normal temperatures and pressures.
Incompatibilities
Strong oxidizing agents.
Decomposition
Carbon monoxide, Carbon dioxide, Nitrogen oxides.

Fire.
Fire fighting
Extinguish using Water spray. Carbon dioxide, dry chemical powder, or appropriate foam. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
Fire potential
Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes.
Hazards
Emits toxic fumes under fire conditions.
Combustion products
Fire may produce irritating, corrosive and/or toxic gases.
Health
-
 
Flammability
0
 
 
Reactivity
0
 

Health.
Exposure effects
Toxic by inhalation, in contact with skin and if swallowed. Possible sensitizer. Target organ(s): Heart. Smooth muscle.
   Ingestion
Toxic if swallowed.
   Inhalation
Toxic if inhaled. Material may be irritating to
   Skin
May cause skin irritation. Toxic if absorbed through skin.
   Eyes
May cause eye irritation.

First aid
 
   Ingestion
If swallowed, wash out mouth with water provided person is conscious. Call a physician immediately.
   Inhalation
If inhaled, remove to fresh air. If not breathing give artificial respiration. If breathing is difficult, give oxygen.
   Skin
In case of skin contact, flush with copious amounts of water for at least 15 minutes. Remove contaminated clothing and shoes. Call a physician.
   Eyes
In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician.

Transport.
UN number
2811
Response guide
Hazard class
6.1
Packing Group
III